{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,11]],"date-time":"2026-06-11T01:17:23Z","timestamp":1781140643106,"version":"3.54.1"},"reference-count":49,"publisher":"American Society for Microbiology","issue":"2","license":[{"start":{"date-parts":[[2021,4,28]],"date-time":"2021-04-28T00:00:00Z","timestamp":1619568000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2021,4,28]],"date-time":"2021-04-28T00:00:00Z","timestamp":1619568000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"funder":[{"DOI":"10.13039\/100000002","name":"HHS | National Institutes of Health","doi-asserted-by":"publisher","award":["75N93019C00052"],"award-info":[{"award-number":["75N93019C00052"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008065","name":"Georgia Research Alliance","doi-asserted-by":"publisher","award":["GRA-001"],"award-info":[{"award-number":["GRA-001"]}],"id":[{"id":"10.13039\/100008065","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007699","name":"University of Georgia","doi-asserted-by":"publisher","award":["UGA-001"],"award-info":[{"award-number":["UGA-001"]}],"id":[{"id":"10.13039\/100007699","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["mSphere"],"published-print":{"date-parts":[[2021,4,28]]},"abstract":"<jats:p>H1N1 and H3N2 influenza viruses have cocirculated in the human population since 1977. Nearly every human alive today has antibodies and memory B and T cells against these two subtypes of influenza viruses.<\/jats:p>","DOI":"10.1128\/msphere.00052-21","type":"journal-article","created":{"date-parts":[[2021,3,16]],"date-time":"2021-03-16T08:57:49Z","timestamp":1615885069000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":20,"title":["Broadly Reactive H2 Hemagglutinin Vaccines Elicit Cross-Reactive Antibodies in Ferrets Preimmune to Seasonal Influenza A Viruses"],"prefix":"10.1128","volume":"6","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5685-000X","authenticated-orcid":true,"given":"Z. Beau","family":"Reneer","sequence":"first","affiliation":[{"name":"Center for Vaccines and Immunology, University of Georgia, Athens, Georgia, USA"},{"name":"Department of Infectious Diseases, University of Georgia, Athens, Georgia, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3654-9076","authenticated-orcid":true,"given":"Amanda L.","family":"Skarlupka","sequence":"additional","affiliation":[{"name":"Center for Vaccines and Immunology, University of Georgia, Athens, Georgia, USA"},{"name":"Department of Infectious Diseases, University of Georgia, Athens, Georgia, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Parker J.","family":"Jamieson","sequence":"additional","affiliation":[{"name":"Center for Vaccines and Immunology, University of Georgia, Athens, Georgia, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1947-7469","authenticated-orcid":true,"given":"Ted M.","family":"Ross","sequence":"additional","affiliation":[{"name":"Center for Vaccines and Immunology, University of Georgia, Athens, Georgia, USA"},{"name":"Department of Infectious Diseases, University of Georgia, Athens, Georgia, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","unstructured":"Centers for Disease Control and Prevention. 2019. 1957\u20131958 Pandemic (H2N2 virus). Centers for Disease Control and Prevention Atlanta GA. https:\/\/www.cdc.gov\/flu\/pandemic-resources\/1957-1958-pandemic.html."},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.virol.2004.06.009"},{"key":"e_1_3_2_4_2","volume-title":"Fields virology","author":"Knipe DM","year":"2013","unstructured":"Knipe DM, Howley PM (ed). 2013. Fields virology, 6th ed. Lippincott Williams & Wilkins, Philadelphia, PA.","edition":"6"},{"key":"e_1_3_2_5_2","unstructured":"The College of Physicians of Philadelphia. 2020. The history of vaccines. The College of Physicians of Philadelphia Philadelphia PA. Accessed 20 May 2020. https:\/\/www.historyofvaccines.org\/timeline#EVT_100808."},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.0030167"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11262-008-0235-z"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1637\/11122-050615-ResNote"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11262-016-1368-0"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0050834"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1637\/9749-040111-Reg.1"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0710286104"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.virol.2015.01.002"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1109397109"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2011.01.100"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1128\/CVI.05533-11"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jis232"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1080\/21645515.2015.1012013"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.01581-17"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.01283-17"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.03152-15"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.00946-18"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.02257-12"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.02372-15"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.coi.2014.02.005"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.01526-20"},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20130212"},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.aag1322"},{"key":"e_1_3_2_29_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1008109"},{"key":"e_1_3_2_30_2","doi-asserted-by":"publisher","DOI":"10.3390\/vaccines7040133"},{"key":"e_1_3_2_31_2","unstructured":"BARDA. 2019. Medical countermeasures on U.S. Department of Health and Human Services. https:\/\/medicalcountermeasures.gov. Accessed 20 May 2020."},{"key":"e_1_3_2_32_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.00169-19"},{"key":"e_1_3_2_33_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13073-015-0239-y"},{"key":"e_1_3_2_34_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2016.05.014"},{"key":"e_1_3_2_35_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1005578"},{"key":"e_1_3_2_36_2","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201411-1988OC"},{"key":"e_1_3_2_37_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41541-018-0069-1"},{"key":"e_1_3_2_38_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ebiom.2016.01.003"},{"key":"e_1_3_2_39_2","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jiv181"},{"key":"e_1_3_2_40_2","doi-asserted-by":"publisher","DOI":"10.4149\/av_2019_408"},{"key":"e_1_3_2_41_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.coviro.2013.05.001"},{"key":"e_1_3_2_42_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.74.24.11690-11696.2000"},{"key":"e_1_3_2_43_2","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jix165"},{"key":"e_1_3_2_44_2","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2019.00593"},{"key":"e_1_3_2_45_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0906849106"},{"key":"e_1_3_2_46_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.67.5.2552-2558.1993"},{"key":"e_1_3_2_47_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1308701110"},{"key":"e_1_3_2_48_2","doi-asserted-by":"publisher","DOI":"10.1016\/s0076-6879(00)26068-0"},{"key":"e_1_3_2_49_2","doi-asserted-by":"publisher","DOI":"10.1128\/jvi.77.3.2046-2055.2003"},{"key":"e_1_3_2_50_2","volume-title":"Manual for the laboratory diagnosis and virological surveillance of influenza","author":"World Health Organization","year":"2011","unstructured":"World Health Organization. 2011. Manual for the laboratory diagnosis and virological surveillance of influenza. World Health Organization, Geneva, Switzerland."}],"container-title":["mSphere"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/mSphere.00052-21","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/mSphere.00052-21","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,7]],"date-time":"2022-03-07T23:41:54Z","timestamp":1646696514000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/mSphere.00052-21"}},"subtitle":[],"editor":[{"given":"Michael J.","family":"Imperiale","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2021,4,28]]},"references-count":49,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2021,4,28]]}},"alternative-id":["10.1128\/mSphere.00052-21"],"URL":"https:\/\/doi.org\/10.1128\/msphere.00052-21","relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/2021.02.17.431747","asserted-by":"object"}]},"ISSN":["2379-5042"],"issn-type":[{"value":"2379-5042","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,4,28]]},"assertion":[{"value":"2021-02-17","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-02-18","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-03-10","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e00052-21"}}