{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T06:04:34Z","timestamp":1790834674914,"version":"4.1.0"},"reference-count":52,"publisher":"American Society for Microbiology","issue":"3","license":[{"start":{"date-parts":[[2016,6,8]],"date-time":"2016-06-08T00:00:00Z","timestamp":1465344000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2016,6,22]],"date-time":"2016-06-22T00:00:00Z","timestamp":1466553600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"funder":[{"DOI":"10.13039\/100000968","name":"American Heart Association","doi-asserted-by":"publisher","award":["15SDG24870016"],"award-info":[{"award-number":["15SDG24870016"]}],"id":[{"id":"10.13039\/100000968","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["mSphere"],"published-print":{"date-parts":[[2016,6,22]]},"abstract":"<jats:p>\n            <jats:named-content content-type=\"genus-species\">S. aureus<\/jats:named-content>\n            is the leading cause of infective endocarditis in the developed world, affecting ~40,000 individuals each year in the United States, and the second leading cause of bacteremia (D. R. Murdoch et al., Arch Intern Med 169:463\u2013473, 2009,\n            <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/dx.doi.org\/10.1001\/archinternmed.2008.603\">http:\/\/dx.doi.org\/10.1001\/archinternmed.2008.603<\/jats:ext-link>\n            , and H. Wisplinghoff et al., Clin Infect Dis 39:309\u2013317, 2004,\n            <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/dx.doi.org\/10.1086\/421946\">http:\/\/dx.doi.org\/10.1086\/421946<\/jats:ext-link>\n            ). Even with current medical advances,\n            <jats:named-content content-type=\"genus-species\">S. aureus<\/jats:named-content>\n            bloodstream infections and infective endocarditis carry mortality rates of 20 to 66% (S. Y. Tong et al., Clin Microbiol Rev 28:603\u2013661, 2015,\n            <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/dx.doi.org\/10.1128\/CMR.00134-14\">http:\/\/dx.doi.org\/10.1128\/CMR.00134-14<\/jats:ext-link>\n            ).\n            <jats:named-content content-type=\"genus-species\">S. aureus<\/jats:named-content>\n            lineages associated with human disease worldwide include clonal complex 5 (CC5)\/USA100, CC30\/USA200, CC8\/USA300, CC1\/USA400, and CC45\/USA600. The CC5\/USA100, CC30\/USA200, and CC45\/USA600 lineages cause invasive disease yet remain poorly characterized. USA300 and cytotoxins are central to most\n            <jats:named-content content-type=\"genus-species\">S. aureus<\/jats:named-content>\n            virulence studies, and yet, we find evidence that clonal groups are quite heterogeneous in parameters canonically used to measure virulence, including cytotoxicity, biofilm formation, and blood survival, and that the superantigen profile is an important parameter to consider when defining the virulence of\n            <jats:named-content content-type=\"genus-species\">S. aureus<\/jats:named-content>\n            strains.\n          <\/jats:p>","DOI":"10.1128\/msphere.00071-16","type":"journal-article","created":{"date-parts":[[2016,6,9]],"date-time":"2016-06-09T03:58:05Z","timestamp":1465444685000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":98,"title":["Phenotypes and Virulence among Staphylococcus aureus USA100, USA200, USA300, USA400, and USA600 Clonal Lineages"],"prefix":"10.1128","volume":"1","author":[{"given":"Jessica M.","family":"King","sequence":"first","affiliation":[{"name":"Department of Microbiology, University of Iowa, Carver College of Medicine, Iowa City, Iowa, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katarina","family":"Kulhankova","sequence":"additional","affiliation":[{"name":"Department of Microbiology, University of Iowa, Carver College of Medicine, Iowa City, Iowa, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher S.","family":"Stach","sequence":"additional","affiliation":[{"name":"Department of Microbiology, University of Iowa, Carver College of Medicine, Iowa City, Iowa, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bao G.","family":"Vu","sequence":"additional","affiliation":[{"name":"Department of Microbiology, University of Iowa, Carver College of Medicine, Iowa City, Iowa, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wilmara","family":"Salgado-Pab\u00f3n","sequence":"additional","affiliation":[{"name":"Department of Microbiology, University of Iowa, Carver College of Medicine, Iowa City, Iowa, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1523-1755.2005.00174.x"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.00134-14"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.298.15.1763"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jir389"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0051172"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.00480-08"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.02264-08"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1186\/2193-1801-2-133"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.122108599"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1128\/genomeA.00517-13"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.00189-14"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.00409-10"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1742-4658.2011.08151.x"},{"key":"e_1_3_2_15_2","first-page":"707","article-title":"Four pediatric deaths from community-acquired methicillin-resistant Staphylococcus aureus\u2014Minnesota and North Dakota, 1997-1999","volume":"48","author":"Centers for Disease Control and Prevention","year":"1999","unstructured":"Centers for Disease Control and Prevention . 1999. 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