{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T06:20:44Z","timestamp":1790835644601,"version":"4.1.0"},"reference-count":87,"publisher":"American Society for Microbiology","issue":"3","license":[{"start":{"date-parts":[[2017,6,21]],"date-time":"2017-06-21T00:00:00Z","timestamp":1498003200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2017,6,28]],"date-time":"2017-06-28T00:00:00Z","timestamp":1498608000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"funder":[{"DOI":"10.13039\/100000060","name":"HHS | NIH | National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["R01 AI073843"],"award-info":[{"award-number":["R01 AI073843"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000060","name":"HHS | NIH | National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["R01 AI069223"],"award-info":[{"award-number":["R01 AI069223"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000060","name":"HHS | NIH | National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["K22 AI104805"],"award-info":[{"award-number":["K22 AI104805"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000060","name":"HHS | NIH | National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["R01 AI118880"],"award-info":[{"award-number":["R01 AI118880"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000060","name":"HHS | NIH | National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["F32AI122516"],"award-info":[{"award-number":["F32AI122516"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000057","name":"HHS | NIH | National Institute of General Medical Sciences","doi-asserted-by":"publisher","award":["R01 GM097225"],"award-info":[{"award-number":["R01 GM097225"]}],"id":[{"id":"10.13039\/100000057","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000057","name":"HHS | NIH | National Institute of General Medical Sciences","doi-asserted-by":"publisher","award":["R35 GM118157"],"award-info":[{"award-number":["R35 GM118157"]}],"id":[{"id":"10.13039\/100000057","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"HHS | NIH | National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["T32HL094296"],"award-info":[{"award-number":["T32HL094296"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["mSphere"],"published-print":{"date-parts":[[2017,6,28]]},"abstract":"<jats:p>\n            Hydrogen sulfide (H\n            <jats:sub>2<\/jats:sub>\n            S) is a toxic molecule and a recently described gasotransmitter in vertebrates whose function in bacteria is not well understood. In this work, we describe the transcriptomic response of the major human pathogen\n            <jats:named-content content-type=\"genus-species\">Staphylococcus aureus<\/jats:named-content>\n            to quantified changes in levels of cellular organic reactive sulfur species, which are effector molecules involved in H\n            <jats:sub>2<\/jats:sub>\n            S signaling. We show that nitroxyl (HNO), a recently described signaling intermediate proposed to originate from the interplay of H\n            <jats:sub>2<\/jats:sub>\n            S and nitric oxide, also induces changes in cellular sulfur speciation and transition metal homeostasis, thus linking sulfide homeostasis to an adaptive response to antimicrobial reactive nitrogen species.\n          <\/jats:p>","DOI":"10.1128\/msphere.00082-17","type":"journal-article","created":{"date-parts":[[2017,6,22]],"date-time":"2017-06-22T00:30:33Z","timestamp":1498091433000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":79,"title":["Sulfide Homeostasis and Nitroxyl Intersect via Formation of Reactive Sulfur Species in Staphylococcus aureus"],"prefix":"10.1128","volume":"2","author":[{"given":"Hui","family":"Peng","sequence":"first","affiliation":[{"name":"Department of Chemistry, Indiana University, Bloomington, Indiana, USA"},{"name":"Graduate Program in Biochemistry, Indiana University, Bloomington, Indiana, USA"},{"name":"Department of Molecular and Cellular Biochemistry, Indiana University, Bloomington, Indiana, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiangchuan","family":"Shen","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Indiana University, Bloomington, Indiana, USA"},{"name":"Graduate Program in Biochemistry, Indiana University, Bloomington, Indiana, USA"},{"name":"Department of Molecular and Cellular Biochemistry, Indiana University, Bloomington, Indiana, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katherine A.","family":"Edmonds","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Indiana University, Bloomington, Indiana, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Justin L.","family":"Luebke","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Indiana University, Bloomington, Indiana, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne K.","family":"Hickey","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Indiana University, Bloomington, Indiana, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lauren D.","family":"Palmer","sequence":"additional","affiliation":[{"name":"Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, Tennessee, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feng-Ming James","family":"Chang","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Indiana University, Bloomington, Indiana, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin A.","family":"Bruce","sequence":"additional","affiliation":[{"name":"Department of Biology, Indiana University, Bloomington, Indiana, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas E.","family":"Kehl-Fie","sequence":"additional","affiliation":[{"name":"Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, Tennessee, USA"},{"name":"Department of Microbiology, University of Illinois Urbana\u2013Champaign, Urbana, Illinois, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric P.","family":"Skaar","sequence":"additional","affiliation":[{"name":"Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, Tennessee, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2342-1620","authenticated-orcid":false,"given":"David P.","family":"Giedroc","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Indiana University, Bloomington, Indiana, USA"},{"name":"Department of Molecular and Cellular Biochemistry, Indiana University, Bloomington, Indiana, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M111.288423"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1128\/MMBR.00034-07"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2958.2009.06760.x"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M805951200"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M112.359737"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.2010.06580.x"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1126\/scisignal.2000464"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvq248"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2010.3572"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms5381"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1209855"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1175439"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M201136200"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0504307102"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1509277112"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1321232111"},{"key":"e_1_3_2_18_2","first-page":"68","volume-title":"The chemistry and biology of nitroxyl (HNO)","author":"Ivanovic-Burmazovic I","year":"2017","unstructured":"Ivanovic-Burmazovic I . 2017. HNO generation from NO\u00b7, nitrite, inorganic or organic nitrosyls, and crosstalk with H2S, p 68\u2013104. InDoctorovichFFarmerPJMartiMA (ed), The chemistry and biology of nitroxyl (HNO). Elsevier, Amsterdam, Netherlands."},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1021\/ja2075949"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1021\/bi401110f"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-800934-5.00006-2"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M114.597740"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/0891-5849(95)00034-U"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-800934-5.00001-3"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1006\/abbi.1998.0898"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.10067"},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.1021\/acs.biochem.6b00714"},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.1039\/c5sc04818d"},{"key":"e_1_3_2_29_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M111.220012"},{"key":"e_1_3_2_30_2","doi-asserted-by":"publisher","DOI":"10.1111\/mmi.12835"},{"key":"e_1_3_2_31_2","doi-asserted-by":"publisher","DOI":"10.1021\/acs.biochem.5b00056"},{"key":"e_1_3_2_32_2","doi-asserted-by":"publisher","DOI":"10.1021\/acs.biochem.5b00584"},{"key":"e_1_3_2_33_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M111.234039"},{"key":"e_1_3_2_34_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1614133114"},{"key":"e_1_3_2_35_2","doi-asserted-by":"publisher","DOI":"10.1002\/cmdc.200700016"},{"key":"e_1_3_2_36_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.00735-08"},{"key":"e_1_3_2_37_2","doi-asserted-by":"publisher","DOI":"10.7717\/peerj.717"},{"key":"e_1_3_2_38_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00253-013-4730-3"},{"key":"e_1_3_2_39_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.72.2.972-979.2004"},{"key":"e_1_3_2_40_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1003068"},{"key":"e_1_3_2_41_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2958.1999.01466.x"},{"key":"e_1_3_2_42_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1348-0421.1999.tb02382.x"},{"key":"e_1_3_2_43_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmb.2003.09.007"},{"key":"e_1_3_2_44_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.00420-13"},{"key":"e_1_3_2_45_2","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2164-10-470"},{"key":"e_1_3_2_46_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2016.05.007"},{"key":"e_1_3_2_47_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1733691100"},{"key":"e_1_3_2_48_2","doi-asserted-by":"publisher","DOI":"10.1111\/mmi.12126"},{"key":"e_1_3_2_49_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.aaf1018"},{"key":"e_1_3_2_50_2","doi-asserted-by":"publisher","DOI":"10.1021\/es950417i"},{"key":"e_1_3_2_51_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1742-4658.2011.08195.x"},{"key":"e_1_3_2_52_2","doi-asserted-by":"publisher","DOI":"10.1111\/mmi.12798"},{"key":"e_1_3_2_53_2","doi-asserted-by":"publisher","DOI":"10.1038\/nchembio820"},{"key":"e_1_3_2_54_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1205952109"},{"key":"e_1_3_2_55_2","doi-asserted-by":"publisher","DOI":"10.1128\/JB.00081-07"},{"key":"e_1_3_2_56_2","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2164-10-429"},{"key":"e_1_3_2_57_2","doi-asserted-by":"publisher","DOI":"10.1021\/bi300015u"},{"key":"e_1_3_2_58_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1417816112"},{"key":"e_1_3_2_59_2","doi-asserted-by":"publisher","DOI":"10.1111\/mmi.12794"},{"key":"e_1_3_2_60_2","doi-asserted-by":"publisher","DOI":"10.1128\/JB.00598-07"},{"key":"e_1_3_2_61_2","doi-asserted-by":"publisher","DOI":"10.1128\/JB.183.24.7341-7353.2001"},{"key":"e_1_3_2_62_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2958.2008.06518.x"},{"key":"e_1_3_2_63_2","doi-asserted-by":"publisher","DOI":"10.1128\/JB.188.5.1899-1910.2006"},{"key":"e_1_3_2_64_2","doi-asserted-by":"publisher","DOI":"10.1128\/JB.186.13.4085-4099.2004"},{"key":"e_1_3_2_65_2","doi-asserted-by":"publisher","DOI":"10.1128\/JB.185.2.610-619.2003"},{"key":"e_1_3_2_66_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1004870"},{"key":"e_1_3_2_67_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.112202099"},{"key":"e_1_3_2_68_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0085544"},{"key":"e_1_3_2_69_2","doi-asserted-by":"publisher","DOI":"10.1021\/jm3012036"},{"key":"e_1_3_2_70_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2011.10.021"},{"key":"e_1_3_2_71_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.182.5.1469"},{"key":"e_1_3_2_72_2","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btu170"},{"key":"e_1_3_2_73_2","doi-asserted-by":"publisher","DOI":"10.1038\/nmeth.1923"},{"key":"e_1_3_2_74_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13059-014-0550-8"},{"key":"e_1_3_2_75_2","doi-asserted-by":"publisher","DOI":"10.1101\/gad.1605307"},{"key":"e_1_3_2_76_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.plasmid.2005.05.005"},{"key":"e_1_3_2_77_2","doi-asserted-by":"publisher","DOI":"10.1128\/JB.187.15.5318-5329.2005"},{"key":"e_1_3_2_78_2","doi-asserted-by":"publisher","DOI":"10.1016\/bs.mie.2014.11.039"},{"key":"e_1_3_2_79_2","doi-asserted-by":"publisher","DOI":"10.1021\/ic970587r"},{"key":"e_1_3_2_80_2","doi-asserted-by":"publisher","DOI":"10.1039\/C0MT00050G"},{"key":"e_1_3_2_81_2","doi-asserted-by":"publisher","DOI":"10.1111\/mmi.13630"},{"key":"e_1_3_2_82_2","doi-asserted-by":"publisher","DOI":"10.1038\/nchembio.1834"},{"key":"e_1_3_2_83_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2014.12.017"},{"key":"e_1_3_2_84_2","doi-asserted-by":"publisher","DOI":"10.1021\/acs.inorgchem.5b00831"},{"key":"e_1_3_2_85_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M115.672816"},{"key":"e_1_3_2_86_2","doi-asserted-by":"publisher","DOI":"10.1021\/ja512343w"},{"key":"e_1_3_2_87_2","doi-asserted-by":"publisher","DOI":"10.1021\/ja3009693"},{"key":"e_1_3_2_88_2","doi-asserted-by":"publisher","DOI":"10.1021\/ar500153c"}],"container-title":["mSphere"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/mSphere.00082-17","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/mSphere.00082-17","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,8]],"date-time":"2022-03-08T03:57:49Z","timestamp":1646711869000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/mSphere.00082-17"}},"subtitle":[],"editor":[{"given":"Christina L.","family":"Stallings","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2017,6,28]]},"references-count":87,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2017,6,28]]}},"alternative-id":["10.1128\/mSphere.00082-17"],"URL":"https:\/\/doi.org\/10.1128\/msphere.00082-17","relation":{},"ISSN":["2379-5042"],"issn-type":[{"value":"2379-5042","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,6,28]]},"assertion":[{"value":"2017-02-16","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2017-06-02","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2017-06-21","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e00082-17"}}