{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T09:00:39Z","timestamp":1785402039081,"version":"3.56.0"},"reference-count":120,"publisher":"American Society for Microbiology","issue":"4","license":[{"start":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T00:00:00Z","timestamp":1777334400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T00:00:00Z","timestamp":1777334400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["mSphere"],"published-print":{"date-parts":[[2026,4,28]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title\/>\n                    <jats:p>\n                      The remodels the structure of chromatin (RSC) and the homologous chromatin-remodeling complexes are known to regulate cell cycle progression in various organisms, including\n                      <jats:italic toggle=\"yes\">Saccharomyces cerevisiae<\/jats:italic>\n                      ,\n                      <jats:italic toggle=\"yes\">Drosophila<\/jats:italic>\n                      , and\n                      <jats:italic toggle=\"yes\">Homo sapiens<\/jats:italic>\n                      . In this work, we characterized the role of two novel CTG clade-specific proteins (Nri1 and Nri2) of the RSC complex in the regulation of cell cycle progression in a critical priority fungal pathogen,\n                      <jats:italic toggle=\"yes\">Candida albicans<\/jats:italic>\n                      . We observed that Nri1, alone or along with Nri2, regulates cell cycle progression at multiple stages. The\n                      <jats:italic toggle=\"yes\">nri1\u0394\/\u0394<\/jats:italic>\n                      and\n                      <jats:italic toggle=\"yes\">nri1\u0394\/\u0394 nri2\u0394\/\u0394<\/jats:italic>\n                      mutants exhibited transient cell cycle arrest, defective spindle morphology, and cytokinesis. Transcriptomic analysis supported these mutant phenotypes and indicated a broad role of Nri proteins in the cell cycle. From our results, we conclude that Nri proteins are crucial for\n                      <jats:italic toggle=\"yes\">C. albicans<\/jats:italic>\n                      proliferation and fitness.\n                    <\/jats:p>\n                    <jats:sec>\n                      <jats:title>IMPORTANCE<\/jats:title>\n                      <jats:p>\n                        The composition of the essential RSC chromatin-remodeling complex exhibits species-specific divergence, harboring unique subunits with distinct functions. In this study, we report that two fungal CTG clade-specific proteins of the\n                        <jats:italic toggle=\"yes\">C. albicans<\/jats:italic>\n                        RSC complex, namely Nri1 and Nri2, can promote\n                        <jats:italic toggle=\"yes\">C. albicans<\/jats:italic>\n                        fitness by regulating its cell cycle progression at multiple stages. Fitness defects, along with stressor sensitivity and differential expression of the genes regulating pathogenesis in the\n                        <jats:italic toggle=\"yes\">nri<\/jats:italic>\n                        mutants, indicate the potential of the Nri proteins in the regulation of\n                        <jats:italic toggle=\"yes\">C. albicans<\/jats:italic>\n                        virulence.\n                      <\/jats:p>\n                    <\/jats:sec>\n                  <\/jats:sec>","DOI":"10.1128\/msphere.00084-26","type":"journal-article","created":{"date-parts":[[2026,3,30]],"date-time":"2026-03-30T12:00:15Z","timestamp":1774872015000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":0,"title":["CTG clade-specific proteins of the RSC chromatin-remodeling complex regulate cell cycle progression of a critical priority fungal pathogen,\n                    <i>Candida 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