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Successful strategies of intervention in RVFV transmission by its mosquito vectors and the prevention of human and veterinary disease rely on a better understanding of the mechanisms that govern RVFV-vector interactions. Despite its medical importance, little is known about the factors that govern RVFV replication, dissemination, and transmission in the invertebrate host. Here we studied the role of the antiviral RNA interference immune pathways in the defense against RVFV in natural vector mosquitoes and mosquito cells and draw comparisons to the model insect\n            <jats:named-content content-type=\"genus-species\">Drosophila melanogaster<\/jats:named-content>\n            . We found that RVFV infection induces both the exogenous small interfering RNA (siRNA) and piRNA pathways, which contribute to the control of viral replication in insects. Furthermore, we demonstrate the production of virus-derived piRNAs in\n            <jats:named-content content-type=\"genus-species\">Culex quinquefasciatus<\/jats:named-content>\n            mosquitoes. Understanding these pathways and the targets within them offers the potential of the development of novel RVFV control measures in vector-based strategies.\n          <\/jats:p>","DOI":"10.1128\/msphere.00090-17","type":"journal-article","created":{"date-parts":[[2017,5,4]],"date-time":"2017-05-04T00:40:28Z","timestamp":1493858428000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":64,"title":["RNA Interference Restricts Rift Valley Fever Virus in Multiple Insect Systems"],"prefix":"10.1128","volume":"2","author":[{"given":"Isabelle","family":"Dietrich","sequence":"first","affiliation":[{"name":"MRC-University of Glasgow Centre for Virus Research, Glasgow, Scotland, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephanie","family":"Jansen","sequence":"additional","affiliation":[{"name":"Bernhard-Nocht-Institut f\u00fcr Tropenmedizin, Hamburg, 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