{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,21]],"date-time":"2026-04-21T01:32:48Z","timestamp":1776735168857,"version":"3.51.2"},"reference-count":33,"publisher":"American Society for Microbiology","issue":"3","license":[{"start":{"date-parts":[[2016,6,15]],"date-time":"2016-06-15T00:00:00Z","timestamp":1465948800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2016,6,22]],"date-time":"2016-06-22T00:00:00Z","timestamp":1466553600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["mSphere"],"published-print":{"date-parts":[[2016,6,22]]},"abstract":"<jats:p>\n            Multiple species of herpesviruses from three different lineages of the\n            <jats:italic>Proboscivirus<\/jats:italic>\n            genus (EEHV1\/6, EEHV2\/5, and EEHV3\/4\/7) infect either Asian or African elephants, but the highly lethal hemorrhagic disease is largely confined to Asian elephant calves and is predominantly associated with EEHV1. In the accompanying paper [P. D. Ling et al., mSphere 1(3):e00081-15,\n            <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/dx.doi.org\/10.1128\/mSphere.00081-15\">http:\/\/dx.doi.org\/10.1128\/mSphere.00081-15<\/jats:ext-link>\n            ], we report the complete 206-kb genome of EEHV4, the third different species causing disease in Asian elephants and the first example of a GC-rich branch proboscivirus. To gain insights into the nature and differential properties of these two very anciently diverged lineages of elephant herpesviruses, we describe here several additional unusual features found in the complete GC-rich genome of EEHV4 with particular emphasis on patterns of divergence as well as common unique features that are distinct from those of all other herpesviruses, such as the enlarged AT-rich intergenic domains and gene families, including the large number of vGPCR-like proteins.\n          <\/jats:p>","DOI":"10.1128\/msphere.00091-16","type":"journal-article","created":{"date-parts":[[2016,6,16]],"date-time":"2016-06-16T05:49:06Z","timestamp":1466056146000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":16,"title":["Comparison of the Gene Coding Contents and Other Unusual Features of the GC-Rich and AT-Rich Branch Probosciviruses"],"prefix":"10.1128","volume":"1","author":[{"given":"Paul D.","family":"Ling","sequence":"first","affiliation":[{"name":"Baylor College of Medicine, Houston, Texas, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Simon Y.","family":"Long","sequence":"additional","affiliation":[{"name":"Viral Oncology Program, The Johns Hopkins School of Medicine, Baltimore, Maryland, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jian-Chao","family":"Zong","sequence":"additional","affiliation":[{"name":"Viral Oncology Program, The Johns Hopkins School of Medicine, Baltimore, Maryland, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sarah Y.","family":"Heaggans","sequence":"additional","affiliation":[{"name":"Viral Oncology Program, The Johns Hopkins School of Medicine, Baltimore, Maryland, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiang","family":"Qin","sequence":"additional","affiliation":[{"name":"The Human Genome Sequencing Center, Houston, Texas, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gary S.","family":"Hayward","sequence":"additional","affiliation":[{"name":"Viral Oncology Program, The Johns Hopkins School of Medicine, Baltimore, Maryland, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"235","reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1354\/vp.46-1-97"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1136\/vr.e1212"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1093\/ilar\/ilv041"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1177\/030098589002700212"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.283.5405.1171"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.7589\/2012-07-193"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1002\/1098-2361(2000)19:5<383::AID-ZOO8>3.0.CO;2-X"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.vetmic.2010.05.042"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.01675-14"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.02936-15"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1638\/1042-7260-44.1.136"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1638\/2015-0072.1"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1638\/2015-0074.1"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1638\/2013-0264R1.1"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1136\/vr.e6833"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.01673-14"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jviromet.2012.07.024"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1638\/1042-7260-44.1.42"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.2460\/ajvr.71.8.925"},{"key":"e_1_3_3_21_2","first-page":"23","article-title":"Pathogenesis and molecular epidemiology of fatal elephant endotheliotropic disease associated with the expanding Proboscivirus genus of the Betaherpesvirinae","author":"Zong J-C","year":"2008","unstructured":"Zong J-C Latimer EM Heaggans SY Richman LK Hayward GS . 2008. Pathogenesis and molecular epidemiology of fatal elephant endotheliotropic disease associated with the expanding Proboscivirus genus of the Betaherpesvirinae, p 23\u201335. InProceedings of the International Elephant Conservation and Research Symposium.","journal-title":"Proceedings of the International Elephant Conservation and Research Symposium"},{"key":"e_1_3_3_22_2","article-title":"Viral gene subtyping of eighteen North American cases of EEHV hemorrhagic disease","author":"Zong J-C","year":"2009","unstructured":"Zong J-C Latimer E Heaggans SY Richman LK Hayward GS . 2009. Viral gene subtyping of eighteen North American cases of EEHV hemorrhagic disease. 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