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We found that the BCG-vaccinated DO mouse population exhibited a wide range of outcomes, in which outcomes in individual mice ranged from minimal respiratory or systemic disease to fulminant disease and death. The breadth of these outcomes appears similar to the range seen in people, indicating that DO mice may serve as an improved small-animal model to study tuberculosis infection and immunity. Moreover, sophisticated tools are available for the use of these mice to map genes contributing to control of vaccination. Thus, the present studies provided an important new tool in the fight against tuberculosis.<\/jats:p>","DOI":"10.1128\/msphere.00097-20","type":"journal-article","created":{"date-parts":[[2020,4,14]],"date-time":"2020-04-14T18:01:10Z","timestamp":1586887270000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":65,"title":["The Diversity Outbred Mouse Population Is an Improved Animal Model of Vaccination against Tuberculosis That Reflects Heterogeneity of Protection"],"prefix":"10.1128","volume":"5","author":[{"given":"Sherry L.","family":"Kurtz","sequence":"first","affiliation":[{"name":"Center for Biologics Evaluation and Research, Food and Drug Administration, Silver Spring, Maryland, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amy P.","family":"Rossi","sequence":"additional","affiliation":[{"name":"University of Cincinnati College of Medicine, Cincinnati, Ohio, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gillian L.","family":"Beamer","sequence":"additional","affiliation":[{"name":"Cummings School of Veterinary Medicine, Tufts University, North Grafton, Massachusetts, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dan M.","family":"Gatti","sequence":"additional","affiliation":[{"name":"College of the Atlantic, Bar Harbor, Maine, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Igor","family":"Kramnik","sequence":"additional","affiliation":[{"name":"Department of Medicine, Boston University School of Medicine, Boston, Massachusetts, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karen L.","family":"Elkins","sequence":"additional","affiliation":[{"name":"Center for Biologics Evaluation and Research, Food and Drug Administration, Silver Spring, Maryland, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tube.2015.04.003"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1007\/s40142-017-0124-7"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1086\/375249"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1086\/648611"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/key059"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1097\/COH.0000000000000501"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.178.6.2249"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/1074-7613(95)90001-2"},{"key":"e_1_3_2_10_2","doi-asserted-by":"crossref","first-page":"293","DOI":"10.4049\/jimmunol.138.1.293","article-title":"The kinetics of emergence and loss of mediator T lymphocytes acquired in response to infection with Mycobacterium tuberculosis","volume":"138","author":"Orme IM","year":"1987","unstructured":"Orme IM. 1987. 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