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Furthermore, TB represents the leading cause of death among people with HIV. HIV is known to cause severe defects in T cell immunity, rendering HIV\/TB-coinfected individuals more susceptible to TB disease progression and complicating accurate TB disease diagnosis. Here, we demonstrate that HIV infection is additionally associated with severely compromised antibody responses, particularly in individuals with active TB. Moreover, despite the influence of HIV infection, antibody profiles still allow accurate classification of individuals with active versus latent TB. These findings reveal novel immunologic challenges associated with HIV\/TB coinfection and additionally provide a basis with which to leverage the key antibody features identified to potentially combat TB globally via next-generation therapeutic or diagnostic design.<\/jats:p>","DOI":"10.1128\/msphere.00104-20","type":"journal-article","created":{"date-parts":[[2020,5,19]],"date-time":"2020-05-19T13:20:06Z","timestamp":1589894406000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":33,"title":["HIV Is Associated with Modified Humoral Immune Responses in the Setting of HIV\/TB Coinfection"],"prefix":"10.1128","volume":"5","author":[{"given":"Esther","family":"van Woudenbergh","sequence":"first","affiliation":[{"name":"Ragon Institute of MGH, MIT, and Harvard, Cambridge, Massachusetts, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edward B.","family":"Irvine","sequence":"additional","affiliation":[{"name":"Ragon Institute of MGH, MIT, and Harvard, Cambridge, Massachusetts, USA"},{"name":"Department of Immunology and Infectious Diseases, Harvard T. 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