{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,17]],"date-time":"2026-01-17T05:23:09Z","timestamp":1768627389627,"version":"3.49.0"},"reference-count":21,"publisher":"American Society for Microbiology","issue":"2","license":[{"start":{"date-parts":[[2016,3,2]],"date-time":"2016-03-02T00:00:00Z","timestamp":1456876800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2016,4,27]],"date-time":"2016-04-27T00:00:00Z","timestamp":1461715200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["mSphere"],"published-print":{"date-parts":[[2016,4,27]]},"abstract":"<jats:p>\n            Noncoding RNAs (ncRNAs) represent an intriguing and diverse class of molecules that are now recognized for their participation in a wide array of cellular processes. Viruses from multiple families have evolved to encode their own such regulatory RNAs; however, the specific\n            <jats:italic>in vivo<\/jats:italic>\n            functions of these ncRNAs are largely unknown. Epstein-Barr virus (EBV) and Kaposi\u2019s sarcoma-associated herpesvirus (KSHV) are ubiquitous human pathogens that are associated with the development of numerous malignancies. Like EBV and KSHV, murine gammaherpesvirus 68 (MHV68) establishes lifelong latency in B cells and is associated with lymphomagenesis. The work described here reveals that the MHV68 ncRNA TMER4 acts at a critical bottleneck in local lymph nodes to facilitate hematogenous dissemination of the virus and establishment of latency at peripheral sites.\n          <\/jats:p>","DOI":"10.1128\/msphere.00105-15","type":"journal-article","created":{"date-parts":[[2016,3,3]],"date-time":"2016-03-03T04:24:09Z","timestamp":1456979049000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":42,"title":["A Gammaherpesvirus Noncoding RNA Is Essential for Hematogenous Dissemination and Establishment of Peripheral Latency"],"prefix":"10.1128","volume":"1","author":[{"given":"Emily R.","family":"Feldman","sequence":"first","affiliation":[{"name":"Department of Molecular Genetics and Microbiology and UF Health Cancer Center, College of Medicine, University of Florida, Gainesville, Florida, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mehmet","family":"Kara","sequence":"additional","affiliation":[{"name":"Department of Molecular Genetics and Microbiology and UF Health Cancer Center, College of Medicine, University of Florida, Gainesville, Florida, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lauren M.","family":"Oko","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, University of Colorado School of Medicine, Aurora, Colorado, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katrina R.","family":"Grau","sequence":"additional","affiliation":[{"name":"Department of Molecular Genetics and Microbiology and UF Health Cancer Center, College of Medicine, University of Florida, Gainesville, Florida, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brian J.","family":"Krueger","sequence":"additional","affiliation":[{"name":"Department of Molecular Genetics and Microbiology and UF Health Cancer Center, College of Medicine, University of Florida, Gainesville, Florida, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Junjie","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Molecular Microbiology and Immunology, Keck School of Medicine, University of Southern California, Los Angeles, California, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pinghui","family":"Feng","sequence":"additional","affiliation":[{"name":"Department of Molecular Microbiology and Immunology, Keck School of Medicine, University of Southern California, Los Angeles, California, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Linda F.","family":"van Dyk","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, University of Colorado School of Medicine, Aurora, Colorado, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rolf","family":"Renne","sequence":"additional","affiliation":[{"name":"Department of Molecular Genetics and Microbiology and UF Health Cancer Center, College of Medicine, University of Florida, Gainesville, Florida, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Scott A.","family":"Tibbetts","sequence":"additional","affiliation":[{"name":"Department of Molecular Genetics and Microbiology and UF Health Cancer Center, College of Medicine, University of Florida, Gainesville, Florida, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"235","reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrg2349"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1099\/0022-1317-78-7-1675"},{"key":"e_1_3_3_4_2","doi-asserted-by":"crossref","unstructured":"Virgin\nHW\nLatreille\nP\nWamsley\nP\nHallsworth\nK\nWeck\nKE\nDal Canto\nAJ\nSpeck\nSH\n. 1997. 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