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Anthropogenic climate change is eroding this thermal barrier, while a concurrent decline in human basal body temperature accelerates convergence from both directions.\n                      <jats:italic toggle=\"yes\">Candida auris<\/jats:italic>\n                      , a thermotolerant, multidrug-resistant pathogen, arose independently as genetically distinct clades on multiple continents, a pattern implicating shared selective pressures rather than clonal spread. Unlike its closest relatives, which grow poorly at mammalian temperatures, it thrives at 37\u00b0C, tolerates up to 47\u00b0C, persists on hospital surfaces, resists all three major antifungal classes, and causes invasive infections with 30\u201360% mortality. We review its evolutionary biology, ecology, and clinical significance, evaluating hypotheses for its origin, and the mechanisms underlying its thermotolerance and virulence.\n                      <jats:italic toggle=\"yes\">C. auris<\/jats:italic>\n                      may be the first of many fungi adapting to breach mammalian thermal defenses, making predictive frameworks for fungal disease emergence an urgent priority.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1128\/msphere.00109-26","type":"journal-article","created":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T13:00:15Z","timestamp":1790946015000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":0,"title":["<i>Candidozyma auris<\/i>\n                    (\n                    <i>Candida auris<\/i>\n                    ) as a harbinger of novel fungal pathogens"],"prefix":"10.1128","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-9313-1694","authenticated-orcid":true,"given":"Carla E.","family":"Schuh","sequence":"first","affiliation":[{"id":[{"id":"https:\/\/ror.org\/00fbnyb24","id-type":"ROR","asserted-by":"publisher"}],"name":"Chair for Computational and Theoretical Biology, University of W\u00fcrzburg","place":["W\u00fcrzburg, Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5749-3665","authenticated-orcid":true,"given":"Chaitanya S.","family":"Gokhale","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/00fbnyb24","id-type":"ROR","asserted-by":"publisher"}],"name":"Chair for Computational and Theoretical Biology, University of W\u00fcrzburg","place":["W\u00fcrzburg, Germany"]},{"id":[{"id":"https:\/\/ror.org\/00fbnyb24","id-type":"ROR","asserted-by":"publisher"}],"name":"Joint Institute for Individualisation in a Changing Environment (JICE), University of W\u00fcrzburg","place":["W\u00fcrzburg, Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","published-online":{"date-parts":[[2026,10,2]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pbio.3000938"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1128\/MMBR.64.3.461-488.2000"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1128\/mBio.01397-19"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-immunol-101220-034306"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1098\/rstb.2001.0888"},{"key":"e_1_3_3_7_2","unstructured":"Nullis C. 2026. 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