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Appropriate antibiotic treatment during early infection prevents disease progression. Unfortunately, currently available diagnostics are suboptimal in the detection of early disease. The inability to confirm\n            <jats:named-content content-type=\"genus-species\">Borrelia<\/jats:named-content>\n            infection using laboratory methods during early disease is, in part, responsible for much of the controversy surrounding Lyme disease today. As a result, there has been significant investment in the identification of new antigen targets to generate diagnostic assays that are more sensitive for the detection of early infection. The importance of our research is that in our evaluation of BBK32, an antigen that was previously identified as a promising target for use in serodiagnostics, we found a high degree of cross-reactivity that could compromise the specificity of assays that utilize this antigen, leading to false-positive diagnoses.\n          <\/jats:p>","DOI":"10.1128\/msphere.00111-19","type":"journal-article","created":{"date-parts":[[2019,4,30]],"date-time":"2019-04-30T12:58:22Z","timestamp":1556629102000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":15,"title":["Linear B Cell Epitopes Derived from the Multifunctional Surface Lipoprotein BBK32 as Targets for the Serodiagnosis of Lyme Disease"],"prefix":"10.1128","volume":"4","author":[{"given":"Christina","family":"Toumanios","sequence":"first","affiliation":[{"name":"Summer Trainees in Academic Research Program, Graduate School of Basic Medical Sciences, New York Medical College, Valhalla, New York, USA"},{"name":"Colgate University, Hamilton, New York, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lauren","family":"Prisco","sequence":"additional","affiliation":[{"name":"Summer Trainees in Academic Research Program, Graduate School of Basic Medical Sciences, New York Medical College, Valhalla, New York, USA"},{"name":"Cornell University, Ithaca, New York, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raymond J.","family":"Dattwyler","sequence":"additional","affiliation":[{"name":"Biopeptides Corp., East Setauket, New York, USA"},{"name":"Department of Microbiology and Immunology, New York Medical College, Valhalla, New York, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4005-4412","authenticated-orcid":false,"given":"Paul M.","family":"Arnaboldi","sequence":"additional","affiliation":[{"name":"Biopeptides Corp., East Setauket, New York, USA"},{"name":"Department of Microbiology and Immunology, New York Medical College, Valhalla, New York, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.18.3.484-509.2005"},{"key":"e_1_3_2_3_2","first-page":"590","article-title":"Recommendations for test performance and interpretation from the Second National Conference on Serologic Diagnosis of Lyme Disease","volume":"44","author":"Centers for Disease Control and Prevention (CDC)","year":"1995","unstructured":"Centers for Disease Control and Prevention (CDC). 1995. 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