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Melioidosis is endemic in Southeast Asia and northern Australia; however, the global distribution of<jats:named-content content-type=\"genus-species\">B. pseudomallei<\/jats:named-content>and the disease burden of melioidosisis are still poorly understood. Melioidosis is difficult to treat, as<jats:named-content content-type=\"genus-species\">B. pseudomallei<\/jats:named-content>is intrinsically resistant to many antibiotics and requires a long course of antibiotic treatment. The mortality rates remain high in areas of endemicity, with reoccurrence being common. Therefore, it is imperative to diagnose the disease at an early stage and provide vital clinical care to reduce the mortality rate. With limitations in treatment and lack of a vaccine, it is crucial to study the immune response mechanisms to this infection to get a better understanding of disease susceptibility and pathogenesis. 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