{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T17:05:54Z","timestamp":1779383154584,"version":"3.53.1"},"reference-count":35,"publisher":"American Society for Microbiology","issue":"4","license":[{"start":{"date-parts":[[2018,7,18]],"date-time":"2018-07-18T00:00:00Z","timestamp":1531872000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2018,8,29]],"date-time":"2018-08-29T00:00:00Z","timestamp":1535500800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31625026"],"award-info":[{"award-number":["31625026"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["mSphere"],"published-print":{"date-parts":[[2018,8,29]]},"abstract":"<jats:p>\n            Worldwide spread of antibiotic resistance genes among\n            <jats:italic>Enterobacteriaceae<\/jats:italic>\n            isolates is of great concern. F33:A\u2212:B\u2212 plasmids are important vectors of resistance genes, such as\n            <jats:italic>bla<\/jats:italic>\n            <jats:sub>CTX-M-55\/-65<\/jats:sub>\n            ,\n            <jats:italic>bla<\/jats:italic>\n            <jats:sub>NDM-1<\/jats:sub>\n            ,\n            <jats:italic>fosA3<\/jats:italic>\n            , and\n            <jats:italic>rmtB<\/jats:italic>\n            , among\n            <jats:named-content content-type=\"genus-species\">E.\u00a0coli<\/jats:named-content>\n            isolates from various sources in China. We determined and compared the complete sequences of 17 F33:A\u2212:B\u2212 plasmids from various sources. These plasmids appear to have evolved from the same ancestor by mobile element-mediated rearrangement, acquisition, and\/or loss of resistance modules and similar IncN1, IncI1, and\/or IncX1 plasmid backbone segments. Our findings highlight the evolutionary potential of F33:A\u2212:B\u2212 plasmids as efficient vectors to capture and diffuse clinically relevant resistance genes.\n          <\/jats:p>","DOI":"10.1128\/msphere.00137-18","type":"journal-article","created":{"date-parts":[[2018,7,17]],"date-time":"2018-07-17T11:54:03Z","timestamp":1531828443000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":51,"title":["Evolution and Comparative Genomics of F33:A\u2212:B\u2212 Plasmids Carrying\n            <i>bla<\/i>\n            <sub>CTX-M-55<\/sub>\n            or\n            <i>bla<\/i>\n            <sub>CTX-M-65<\/sub>\n            in\n            <i>Escherichia coli<\/i>\n            and\n            <i>Klebsiella pneumoniae<\/i>\n            Isolated from Animals, Food Products, and Humans in China"],"prefix":"10.1128","volume":"3","author":[{"given":"Jing","family":"Wang","sequence":"first","affiliation":[{"name":"College of Veterinary Medicine, Key Laboratory of Zoonosis of Ministry of Agricultural and Rural Affairs, South China Agricultural University, Guangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhen-Ling","family":"Zeng","sequence":"additional","affiliation":[{"name":"College of Veterinary Medicine, Key Laboratory of Zoonosis of Ministry of Agricultural and Rural Affairs, South China Agricultural University, Guangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin-Yi","family":"Huang","sequence":"additional","affiliation":[{"name":"College of Veterinary Medicine, Key Laboratory of Zoonosis of Ministry of Agricultural and Rural Affairs, South China Agricultural University, Guangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhen-Bao","family":"Ma","sequence":"additional","affiliation":[{"name":"College of Veterinary Medicine, Key Laboratory of Zoonosis of Ministry of Agricultural and Rural Affairs, South 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