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It is also a major cause of infections in patients with cystic fibrosis.\n                    <jats:named-content content-type=\"genus-species\">P. aeruginosa<\/jats:named-content>\n                    is intrinsically resistant to a number of drugs and is capable of forming biofilms that are difficult to eradicate with antibiotics. The number of drug-resistant strains is also increasing, making treatment of\n                    <jats:named-content content-type=\"genus-species\">P. aeruginosa<\/jats:named-content>\n                    infections very difficult. Thus, there is an urgent need to understand how\n                    <jats:named-content content-type=\"genus-species\">P. aeruginosa<\/jats:named-content>\n                    causes disease in order to find novel ways to treat infections. We show that the principal redox buffer, glutathione (GSH), is involved in intrinsic resistance to the fosfomycin and rifampin antibiotics. We further demonstrate that GSH plays a role in\n                    <jats:named-content content-type=\"genus-species\">P. aeruginosa<\/jats:named-content>\n                    disease and infection, since a mutant lacking GSH has less biofilm formation, is less able to swarm, and produces less pyocyanin, a pigment associated with infection.\n                  <\/jats:p>","DOI":"10.1128\/msphere.00155-18","type":"journal-article","created":{"date-parts":[[2018,4,17]],"date-time":"2018-04-17T05:54:03Z","timestamp":1523944443000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":34,"title":["Pseudomonas aeruginosa\n                    <i>gshA<\/i>\n                    Mutant Is Defective in Biofilm Formation, Swarming, and Pyocyanin Production"],"prefix":"10.1128","volume":"3","author":[{"given":"Tricia A.","family":"Van Laar","sequence":"first","affiliation":[{"name":"Department of Biology, California State University\u2014Fresno, Fresno, California, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saika","family":"Esani","sequence":"additional","affiliation":[{"name":"Department of Biology, California State University\u2014Fresno, Fresno, California, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tyler J.","family":"Birges","sequence":"additional","affiliation":[{"name":"Department of Biology, California State University\u2014Fresno, Fresno, California, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bethany","family":"Hazen","sequence":"additional","affiliation":[{"name":"Department of Biology, California State University\u2014Fresno, Fresno, California, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jason M.","family":"Thomas","sequence":"additional","affiliation":[{"name":"Department of Biology, California State University\u2014Fresno, Fresno, California, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mamta","family":"Rawat","sequence":"additional","affiliation":[{"name":"Department of Biology, California State University\u2014Fresno, Fresno, California, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.3109\/10408419709115130"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.2174\/1568026013395605"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1005932"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1093\/clinids\/5.2.279"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pcbi.1004452"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1128\/mBio.00073-12"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1128\/JB.00157-09"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1128\/iai.56.9.2515-2517.1988"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1128\/MMBR.05007-11"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2006.8.753"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbagen.2012.09.008"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1111\/mmi.12119"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1005741"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature14029"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1002813"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1003582"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1004518"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.2175\/106143013X13807328849855"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1128\/EC.4.9.1562-1573.2005"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1099\/00221287-148-4-923"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1128\/JB.187.2.771-777.2005"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2958.1997.3291701.x"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1211037"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tim.2012.08.009"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrmicro2333"},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2007.08.142"},{"key":"e_1_3_2_28_2","first-page":"603","article-title":"Impact of glutathione on the gene expression of exoY and exoS in Pseudomonas aeruginosa","volume":"49","author":"Zhang Y","year":"2009","unstructured":"Zhang Y, Wei Y. 2009. 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