{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T18:41:11Z","timestamp":1761676871614,"version":"3.41.2"},"reference-count":23,"publisher":"American Society for Microbiology","issue":"4","license":[{"start":{"date-parts":[[2020,7,15]],"date-time":"2020-07-15T00:00:00Z","timestamp":1594771200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2020,8,26]],"date-time":"2020-08-26T00:00:00Z","timestamp":1598400000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"funder":[{"DOI":"10.13039\/501100018537","name":"National Science and Technology Major Project","doi-asserted-by":"crossref","award":["2018ZX10201001-003"],"award-info":[{"award-number":["2018ZX10201001-003"]}],"id":[{"id":"10.13039\/501100018537","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Beijing Municipal Natural Science Foundation","award":["5172029"],"award-info":[{"award-number":["5172029"]}]}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["mSphere"],"published-print":{"date-parts":[[2020,8,26]]},"abstract":"<jats:p>\n            Beijing is the largest transportation hub in China, with a highly mobile population.\n            <jats:named-content content-type=\"genus-species\">Shigella flexneri<\/jats:named-content>\n            is a major cause of bacillary dysentery in Beijing. However, little is known about the genetic features and population structure of locally circulating\n            <jats:named-content content-type=\"genus-species\">S. flexneri<\/jats:named-content>\n            clones. Whole-genome sequencing of 93\n            <jats:named-content content-type=\"genus-species\">S. flexneri<\/jats:named-content>\n            isolates revealed that\n            <jats:named-content content-type=\"genus-species\">S. flexneri<\/jats:named-content>\n            epidemics in Beijing were predominantly caused by an ST100 clone. Interregional spread, rapid local expansion, and acquirement of antimicrobial resistance determinants have cocontributed to the epidemics of this clone. Another ST18 clone was also identified and showed long-term colonization in Beijing. Our study provides comprehensive insights into the population structure and evolutionary history of\n            <jats:named-content content-type=\"genus-species\">S. flexneri<\/jats:named-content>\n            in Beijing.\n          <\/jats:p>","DOI":"10.1128\/msphere.00161-20","type":"journal-article","created":{"date-parts":[[2020,7,14]],"date-time":"2020-07-14T14:30:02Z","timestamp":1594737002000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":2,"title":["Phylogenetic Characterization Reveals Prevalent Shigella flexneri ST100 Clone in Beijing, China, 2005 to 2018"],"prefix":"10.1128","volume":"5","author":[{"given":"Lang","family":"Yang","sequence":"first","affiliation":[{"name":"Academy of Military Medical Sciences, Beijing, China"},{"name":"Chinese PLA Center for Disease Control and Prevention, Beijing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bing","family":"L\u00fc","sequence":"additional","affiliation":[{"name":"Institute for Infectious Disease and Endemic Disease Control, Beijing Center for Disease Prevention and Control, Beijing Research Center for Preventive Medicine, Beijing Key Laboratory of Diagnostic and Traceability Technologies for Food Poisoning, Beijing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Quanyi","family":"Wang","sequence":"additional","affiliation":[{"name":"Institute for Infectious Disease and Endemic Disease Control, Beijing Center for Disease Prevention and Control, Beijing Research Center for Preventive Medicine, Beijing Key Laboratory of Diagnostic and Traceability Technologies for Food Poisoning, Beijing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kaiying","family":"Wang","sequence":"additional","affiliation":[{"name":"Academy of Military Medical Sciences, Beijing, China"},{"name":"Chinese PLA Center for Disease Control and Prevention, Beijing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yanfeng","family":"Lin","sequence":"additional","affiliation":[{"name":"Academy of Military Medical Sciences, Beijing, China"},{"name":"Chinese PLA Center for Disease Control and Prevention, Beijing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chaojie","family":"Yang","sequence":"additional","affiliation":[{"name":"Chinese PLA Center for Disease Control and Prevention, Beijing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shaofu","family":"Qiu","sequence":"additional","affiliation":[{"name":"Chinese PLA Center for Disease Control and Prevention, Beijing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3145-887X","authenticated-orcid":false,"given":"Peng","family":"Li","sequence":"additional","affiliation":[{"name":"Chinese PLA Center for Disease Control and Prevention, Beijing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hongbin","family":"Song","sequence":"additional","affiliation":[{"name":"Chinese PLA Center for Disease Control and Prevention, Beijing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","first-page":"651","article-title":"Global burden of Shigella infections: implications for vaccine development and implementation of control strategies","volume":"77","author":"Kotloff KL","year":"1999","unstructured":"Kotloff KL, Winickoff JP, Ivanoff B, Clemens JD, Swerdlow DL, Sansonetti PJ, Adak GK, Levine MM. 1999. 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