{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T06:59:43Z","timestamp":1790492383234,"version":"4.1.0"},"reference-count":43,"publisher":"American Society for Microbiology","issue":"2","license":[{"start":{"date-parts":[[2020,3,25]],"date-time":"2020-03-25T00:00:00Z","timestamp":1585094400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2020,4,29]],"date-time":"2020-04-29T00:00:00Z","timestamp":1588118400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"funder":[{"DOI":"10.13039\/100000060","name":"HHS | NIH | National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["1P01 AI117915"],"award-info":[{"award-number":["1P01 AI117915"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["mSphere"],"published-print":{"date-parts":[[2020,4,29]]},"abstract":"<jats:p>The majority of new HIV-1 infections occur in young adults, with adolescent women being 3 times more likely to acquire HIV than young men. Implementation of HIV prevention strategies has been less successful in this age group; thus, a vaccine given prior to adolescence remains a high priority. We propose that instead of starting HIV vaccination during adolescence, an HIV vaccine regimen initiated in early infancy, aligned with the well-accepted pediatric vaccine schedule and followed with booster immunizations, will provide an alternative means to reduce HIV acquisition in adolescence. Importantly, the long window of time between the first infant vaccine dose and the adolescence vaccine dose will allow for the maturation of highly functional HIV Env-specific antibody responses. Our study provides evidence that early life vaccination induces durable Env-specific plasma IgG responses that can be boosted to further improve the quality of the antibody response.<\/jats:p>","DOI":"10.1128\/msphere.00162-20","type":"journal-article","created":{"date-parts":[[2020,4,7]],"date-time":"2020-04-07T16:12:02Z","timestamp":1586275922000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":11,"title":["HIV Env-Specific IgG Antibodies Induced by Vaccination of Neonatal Rhesus Macaques Persist and Can Be Augmented by a Late Booster Immunization in Infancy"],"prefix":"10.1128","volume":"5","author":[{"suffix":"II","given":"Alan D.","family":"Curtis","sequence":"first","affiliation":[{"name":"Department of Microbiology and Immunology, Center for AIDS Research, and Children\u2019s Research Institute, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Dennis","sequence":"additional","affiliation":[{"name":"Duke Human Vaccine Institute, Duke University Medical Center, Durham, North Carolina, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joshua","family":"Eudailey","sequence":"additional","affiliation":[{"name":"Duke Human Vaccine Institute, Duke University Medical Center, Durham, North Carolina, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Korey L.","family":"Walter","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Immunology, and Parasitology, Louisiana State University Health Sciences Center, New Orleans, Louisiana, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenneth","family":"Cronin","sequence":"additional","affiliation":[{"name":"Duke Human Vaccine Institute, Duke University Medical Center, Durham, North Carolina, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S. Munir","family":"Alam","sequence":"additional","affiliation":[{"name":"Duke Human Vaccine Institute, Duke University Medical Center, Durham, North Carolina, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neelima","family":"Choudhary","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, Center for AIDS Research, and Children\u2019s Research Institute, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryan H.","family":"Tuck","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, Center for AIDS Research, and Children\u2019s Research Institute, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Hudgens","sequence":"additional","affiliation":[{"name":"Department of Biostatistics, Gillings School of Public Health, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pamela A.","family":"Kozlowski","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Immunology, and Parasitology, Louisiana State University Health Sciences Center, New Orleans, Louisiana, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Justin","family":"Pollara","sequence":"additional","affiliation":[{"name":"Duke Human Vaccine Institute, Duke University Medical Center, Durham, North Carolina, USA"},{"name":"Department of Surgery, Duke University School of Medicine, Durham, North Carolina, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guido","family":"Ferrari","sequence":"additional","affiliation":[{"name":"Duke Human Vaccine Institute, Duke University Medical Center, Durham, North Carolina, USA"},{"name":"Department of Surgery, Duke University School of Medicine, Durham, North Carolina, USA"},{"name":"Department of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, North Carolina, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7375-1337","authenticated-orcid":false,"given":"Koen K. A.","family":"Van Rompay","sequence":"additional","affiliation":[{"name":"California National Primate Research Center, University of California at Davis, Davis, California, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sallie","family":"Permar","sequence":"additional","affiliation":[{"name":"Duke Human Vaccine Institute, Duke University Medical Center, Durham, North Carolina, USA"},{"name":"Department of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, North Carolina, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristina","family":"De Paris","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, Center for AIDS Research, and Children\u2019s Research Institute, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","unstructured":"UNAIDS. 2019. Global HIV and AIDS statistics\u2013update 2019. https:\/\/www.unaids.org\/en\/resources\/fact-sheet. Accessed 11 November 2019."},{"key":"e_1_3_2_3_2","unstructured":"UNAIDS. 2019. Women and HIV. A spotlight on adolescent girls and young women. https:\/\/www.unaids.org\/sites\/default\/files\/media_asset\/2019_women-and-hiv_en.pdf."},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.7448\/IAS.20.4.21520"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1177\/2325957415623261"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1007\/s40506-015-0046-4"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciu420"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1080\/14712598.2017.1282457"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1080\/21645515.2016.1276138"},{"key":"e_1_3_2_10_2","first-page":"59","article-title":"Expanded programme on immunization","volume":"41","author":"Keja K","year":"1988","unstructured":"Keja K, Chan C, Hayden G, Henderson RH. 1988. Expanded programme on immunization. World Health Stat Q 41:59\u201363.","journal-title":"World Health Stat Q"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jiu444"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.01070-17"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1128\/CVI.00231-17"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.01051-18"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1089\/AID.2018.0180"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.01783-18"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-0-387-25640-5"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ab.2016.03.007"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jim.2013.11.026"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms15711"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.02119-18"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1111\/imr.12075"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.00878-18"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2016.05.055"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.coi.2018.04.025"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.3390\/vaccines7030119"},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.02182-16"},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.4414\/smw.2017.14465"},{"key":"e_1_3_2_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(12)70088-9"},{"key":"e_1_3_2_30_2","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jis478"},{"key":"e_1_3_2_31_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0908492"},{"key":"e_1_3_2_32_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.01023-12"},{"key":"e_1_3_2_33_2","doi-asserted-by":"publisher","DOI":"10.1086\/521679"},{"key":"e_1_3_2_34_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2003.07.020"},{"key":"e_1_3_2_35_2","doi-asserted-by":"publisher","DOI":"10.1128\/CVI.00717-15"},{"key":"e_1_3_2_36_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmjgh-2018-001363"},{"key":"e_1_3_2_37_2","unstructured":"National Foundation for Infectious Diseases. 2016. Call to action: addressing new and ongoing adolescent vaccination challenges. https:\/\/www.nfid.org\/wp-content\/uploads\/2019\/08\/call-to-action-adolescent-vaccination-challenges.pdf."},{"key":"e_1_3_2_38_2","doi-asserted-by":"publisher","DOI":"10.17226\/12910"},{"key":"e_1_3_2_39_2","unstructured":"Council for International Organization of Medical Sciences The International Council for Laboratory Animal Science. 2012. International guiding principles for biomedical research involving animals. https:\/\/grants.nih.gov\/grants\/olaw\/Guiding_Principles_2012.pdf."},{"key":"e_1_3_2_40_2","doi-asserted-by":"publisher","DOI":"10.1038\/mi.2016.32"},{"key":"e_1_3_2_41_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI81593"},{"key":"e_1_3_2_42_2","doi-asserted-by":"publisher","DOI":"10.1002\/cyto.a.21084"},{"key":"e_1_3_2_43_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V90.3.1109"},{"key":"e_1_3_2_44_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-59745-170-3_26"}],"container-title":["mSphere"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/mSphere.00162-20","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/mSphere.00162-20","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,8]],"date-time":"2022-03-08T04:34:19Z","timestamp":1646714059000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/mSphere.00162-20"}},"subtitle":[],"editor":[{"given":"Helene F.","family":"Rosenberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2020,4,29]]},"references-count":43,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2020,4,29]]}},"alternative-id":["10.1128\/mSphere.00162-20"],"URL":"https:\/\/doi.org\/10.1128\/msphere.00162-20","relation":{},"ISSN":["2379-5042"],"issn-type":[{"value":"2379-5042","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,4,29]]},"assertion":[{"value":"2020-02-18","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-03-12","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-03-25","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e00162-20"}}