{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T17:05:18Z","timestamp":1790528718112,"version":"4.1.0"},"reference-count":27,"publisher":"American Society for Microbiology","issue":"3","license":[{"start":{"date-parts":[[2020,5,27]],"date-time":"2020-05-27T00:00:00Z","timestamp":1590537600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2020,6,24]],"date-time":"2020-06-24T00:00:00Z","timestamp":1592956800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"funder":[{"name":"European Union's Horizon 2020 Research and Innovation Programme Grant Agreement","award":["861917-SAFI"],"award-info":[{"award-number":["861917-SAFI"]}]},{"name":"Zhejiang Provincial Key R & D Program of China","award":["2020C02032"],"award-info":[{"award-number":["2020C02032"]}]},{"name":"National Program on Key Reearch Project","award":["2017YFC1600103"],"award-info":[{"award-number":["2017YFC1600103"]}]},{"name":"National Program on Key Reearch Project","award":["2018YFD0500501"],"award-info":[{"award-number":["2018YFD0500501"]}]},{"name":"National Program on Key Reearch Project","award":["SQ2019YFE010999"],"award-info":[{"award-number":["SQ2019YFE010999"]}]},{"name":"Zhejiang Provincial Natural Science Foundation of China","award":["LR19C180001"],"award-info":[{"award-number":["LR19C180001"]}]}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["mSphere"],"published-print":{"date-parts":[[2020,6,24]]},"abstract":"<jats:p>\n            Human infections caused by\n            <jats:italic>Salmonella<\/jats:italic>\n            Newport generally lead to gastrointestinal diseases. These infections are normally self-limiting; however, in certain cases, broad-spectrum antimicrobials are prescribed for the treatment. The Chinese National Foodborne Disease Surveillance Network has reported a gradual increase in the incidence of multidrug-resistant\n            <jats:italic>S<\/jats:italic>\n            . Newport infections in humans. After careful evaluation of the dynamic relationship among the clinical findings, the age group, and the genomic sequence data, it was found that young patients represented the major group with persistent diarrhea, whereas adults were either asymptomatic or diarrheic. Furthermore, all these strains contained multiple acquired antimicrobial resistance determinants, which limited the use of antimicrobials for human patients of all age groups. This analysis of the laboratory-confirmed cases, coupled with genetic analysis of the corresponding pathogen, revealed that antimicrobial treatment of persistent infections by\n            <jats:italic>S<\/jats:italic>\n            . Newport in infants and toddlers, and in asymptomatic or diarrheic adults, may not be successful. If the antimicrobials must be prescribed at all, they must be used with caution because of the presence of multiple acquired antimicrobial resistance determinants in such strains.\n          <\/jats:p>","DOI":"10.1128\/msphere.00163-20","type":"journal-article","created":{"date-parts":[[2020,5,26]],"date-time":"2020-05-26T14:17:07Z","timestamp":1590502627000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":44,"title":["Persistent Asymptomatic Human Infections by Salmonella enterica Serovar Newport in China"],"prefix":"10.1128","volume":"5","author":[{"given":"Narayan","family":"Paudyal","sequence":"first","affiliation":[{"name":"CATG Microbiology &amp; Food Safety Laboratory, Institute of Preventive Veterinary Science &amp; Department of Veterinary Medicine, Zhejiang University College of Animal Sciences, Hangzhou, China"},{"name":"Animal Health Research Division, Nepal Agricultural Research Council, Kathmandu, Nepal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hang","family":"Pan","sequence":"additional","affiliation":[{"name":"CATG Microbiology &amp; 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