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This study highlights how animals in captivity are vulnerable to novel opportunistic pathogens, many of which do not result in straightforward diagnosis from symptoms and histopathology. In this study, a novel pathogen was suspected to have contributed to the death of a juvenile polar bear. HTS techniques were employed, and a novel\n            <jats:italic>Mastadenovirus<\/jats:italic>\n            was isolated. The virus was present in both the tissue and blood samples. Phylogenetic analysis of the virus at both the gene and genome levels revealed that it is highly divergent to other known mastadenoviruses. Overall, this study shows that animals in isolated conditions still come into contact with novel pathogens, and for many of these pathogens, the host reservoir and mode of transmission are yet to be determined.\n          <\/jats:p>","DOI":"10.1128\/msphere.00171-18","type":"journal-article","created":{"date-parts":[[2018,8,7]],"date-time":"2018-08-07T09:44:04Z","timestamp":1533635044000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":11,"title":["Novel Divergent Polar Bear-Associated Mastadenovirus Recovered from a Deceased Juvenile Polar Bear"],"prefix":"10.1128","volume":"3","author":[{"given":"Anisha","family":"Dayaram","sequence":"first","affiliation":[{"name":"Leibniz Institute for Zoo and Wildlife Research, Berlin, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyriakos","family":"Tsangaras","sequence":"additional","affiliation":[{"name":"Department of Translational Genetics, The Cyprus Institute of Neurology and Genetics, Nicosia, Cyprus"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Selvaraj","family":"Pavulraj","sequence":"additional","affiliation":[{"name":"Institut f\u00fcr Virologie, Zentrum f\u00fcr Infektionsmedizin, Freie Universit\u00e4t Berlin, Berlin, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Walid","family":"Azab","sequence":"additional","affiliation":[{"name":"Institut f\u00fcr Virologie, Zentrum f\u00fcr Infektionsmedizin, Freie Universit\u00e4t Berlin, Berlin, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicole","family":"Groenke","sequence":"additional","affiliation":[{"name":"Institut f\u00fcr Virologie, Zentrum f\u00fcr Infektionsmedizin, Freie Universit\u00e4t Berlin, Berlin, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gudrun","family":"Wibbelt","sequence":"additional","affiliation":[{"name":"Leibniz Institute for Zoo and Wildlife Research, Berlin, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Florian","family":"Sicks","sequence":"additional","affiliation":[{"name":"Tierpark Berlin, Berlin, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nikolaus","family":"Osterrieder","sequence":"additional","affiliation":[{"name":"Institut f\u00fcr Virologie, Zentrum f\u00fcr Infektionsmedizin, Freie Universit\u00e4t Berlin, Berlin, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alex D.","family":"Greenwood","sequence":"additional","affiliation":[{"name":"Leibniz Institute for Zoo and Wildlife Research, Berlin, Germany"},{"name":"Institut f\u00fcr Virologie, Zentrum f\u00fcr Infektionsmedizin, Freie Universit\u00e4t Berlin, Berlin, Germany"},{"name":"Department of Veterinary Medicine, Freie Universit\u00e4t Berlin, Berlin, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2012.07.035"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1638\/2008-0121.1"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1354\/vp.09-VP-0007-D-CR"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1136\/vr.145.13.362"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.3201\/eid1410.080703"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.meegid.2011.03.021"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/0043-1354(95)00070-2"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1099\/vir.0.19497-0"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-375158-4.00010-9"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1099\/vir.0.010090-0"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1099\/vir.0.003087-0"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1089\/hum.2004.15.1167"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.2174\/1566523213666131125095046"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1038\/gt.2012.52"},{"key":"e_1_3_2_16_2","first-page":"35","article-title":"Fox encephalitis (infectious canine hepatitis) in the dog","volume":"31","author":"Chaddock T","year":"1950","unstructured":"Chaddock T, Carlson W. 1950. 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