{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,15]],"date-time":"2026-04-15T14:22:09Z","timestamp":1776262929994,"version":"3.50.1"},"reference-count":70,"publisher":"American Society for Microbiology","issue":"2","license":[{"start":{"date-parts":[[2019,4,3]],"date-time":"2019-04-03T00:00:00Z","timestamp":1554249600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2019,4,24]],"date-time":"2019-04-24T00:00:00Z","timestamp":1556064000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"funder":[{"DOI":"10.13039\/100000072","name":"HHS | NIH | National Institute of Dental and Craniofacial Research","doi-asserted-by":"publisher","award":["R01DE022069-01A1"],"award-info":[{"award-number":["R01DE022069-01A1"]}],"id":[{"id":"10.13039\/100000072","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["mSphere"],"published-print":{"date-parts":[[2019,4,24]]},"abstract":"<jats:p>\n            Many denture wearers suffer from\n            <jats:italic>Candida<\/jats:italic>\n            -associated denture stomatitis (DS), a fungal infection of the hard palate in contact with dentures. Biofilm formation by\n            <jats:named-content content-type=\"genus-species\">Candida albicans<\/jats:named-content>\n            on denture\/palate surfaces is considered a central process in the infection onset. Although\n            <jats:named-content content-type=\"genus-species\">Candida glabrata<\/jats:named-content>\n            is frequently coisolated with\n            <jats:named-content content-type=\"genus-species\">C. albicans<\/jats:named-content>\n            , its role in DS pathogenesis is unknown. We show here, using a contemporary rat model that employed a patented intraoral denture system, that\n            <jats:named-content content-type=\"genus-species\">C. glabrata<\/jats:named-content>\n            established stable colonization on the denture\/palate. However, in contrast to\n            <jats:named-content content-type=\"genus-species\">C. albicans<\/jats:named-content>\n            inoculated rats, rats inoculated with\n            <jats:named-content content-type=\"genus-species\">C. glabrata<\/jats:named-content>\n            exhibited minimal changes in weight gain or palatal tissue damage. Likewise, coinoculation with the two\n            <jats:italic>Candida<\/jats:italic>\n            species resulted in no exacerbation of\n            <jats:named-content content-type=\"genus-species\">C. albicans<\/jats:named-content>\n            -induced DS pathology. Together, our findings indicate that\n            <jats:named-content content-type=\"genus-species\">C. glabrata<\/jats:named-content>\n            has no inducing\/enhancing role in DS pathogenesis.\n          <\/jats:p>","DOI":"10.1128\/msphere.00191-19","type":"journal-article","created":{"date-parts":[[2019,4,2]],"date-time":"2019-04-02T11:53:07Z","timestamp":1554205987000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":17,"title":["Candida glabrata Has No Enhancing Role in the Pathogenesis of\n            <i>Candida<\/i>\n            -Associated Denture Stomatitis in a Rat Model"],"prefix":"10.1128","volume":"4","author":[{"given":"Junko","family":"Yano","sequence":"first","affiliation":[{"name":"Department of Prosthodontics, Louisiana State University Health Sciences Center School of Dentistry, New Orleans, Louisiana, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alika","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Prosthodontics, Louisiana State University Health Sciences Center School of Dentistry, New Orleans, Louisiana, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"suffix":"Jr.","given":"Paul L.","family":"Fidel","sequence":"additional","affiliation":[{"name":"Department of Oral and Craniofacial Biology, Louisiana State University Health Sciences Center School of Dentistry, New Orleans, Louisiana, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mairi C.","family":"Noverr","sequence":"additional","affiliation":[{"name":"Department of Prosthodontics, Louisiana State University Health Sciences Center School of Dentistry, New Orleans, Louisiana, USA"},{"name":"Department of Oral and Craniofacial Biology, Louisiana State University Health Sciences Center School of Dentistry, New Orleans, Louisiana, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0528.1975.tb00291.x"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2842.1987.tb00713.x"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-302X.1990.tb00232.x"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0714.1981.tb01251.x"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2842.2002.00947.x"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0714.2005.00287.x"},{"key":"e_1_3_2_8_2","first-page":"621","article-title":"Comparison of denture stomatitis prevalence in 2 population groups","volume":"19","author":"Zissis A","year":"2006","unstructured":"Zissis A, Yannikakis S, Harrison A. 2006. 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