{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T22:13:53Z","timestamp":1780524833802,"version":"3.54.1"},"reference-count":53,"publisher":"American Society for Microbiology","issue":"4","license":[{"start":{"date-parts":[[2018,8,22]],"date-time":"2018-08-22T00:00:00Z","timestamp":1534896000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2018,8,29]],"date-time":"2018-08-29T00:00:00Z","timestamp":1535500800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["mSphere"],"published-print":{"date-parts":[[2018,8,29]]},"abstract":"<jats:p>The meningococcal antigen typing system (MATS) is an enzyme-linked immunosorbent assay (ELISA) that measures both the levels of expression and the immune reactivity of the three recombinant 4CMenB antigens. Together with PorA variable-region sequence data, this system provides an estimation of how susceptible MenB isolates are to killing by 4CMenB vaccine-induced antibodies. Assays based on subcapsular antigen phenotype analyses, such as MATS, are important in situations where conventional vaccine coverage estimations are not possible. Subcapsular antigens are typically highly diverse across strains, and vaccine coverage estimations would require unfeasibly large efficacy trials and screening of an exhaustive strain panel for antibody functional activity. Here, MATS was applied to all invasive meningococcal serogroup B (MenB) strains isolated over four consecutive epidemiological years (<jats:italic>n<\/jats:italic>= 105) and predicted reasonably high 4CMenB vaccine coverage in the Republic of Ireland.<\/jats:p>","DOI":"10.1128\/msphere.00196-18","type":"journal-article","created":{"date-parts":[[2018,8,28]],"date-time":"2018-08-28T09:50:24Z","timestamp":1535449824000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":21,"title":["Potential Coverage of the 4CMenB Vaccine against Invasive Serogroup B<i>Neisseria meningitidis<\/i>Isolated from 2009 to 2013 in the Republic of Ireland"],"prefix":"10.1128","volume":"3","author":[{"given":"Robert M.","family":"Mulhall","sequence":"first","affiliation":[{"name":"Irish Meningitis and Sepsis Laboratory, Temple Street Children\u2019s University Hospital, Dublin, Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Desiree","family":"Bennett","sequence":"additional","affiliation":[{"name":"Irish Meningitis and Sepsis Laboratory, Temple Street Children\u2019s University Hospital, Dublin, Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Cunney","sequence":"additional","affiliation":[{"name":"Irish Meningitis and Sepsis Laboratory, Temple Street Children\u2019s University Hospital, Dublin, Ireland"},{"name":"Health Protection Surveillance Centre, Dublin, Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ray","family":"Borrow","sequence":"additional","affiliation":[{"name":"Meningococcal Reference Unit, Public Health England, Manchester, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jay","family":"Lucidarme","sequence":"additional","affiliation":[{"name":"Meningococcal Reference Unit, Public Health England, Manchester, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jamie","family":"Findlow","sequence":"additional","affiliation":[{"name":"Meningococcal Reference Unit, Public Health England, Manchester, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keith A.","family":"Jolley","sequence":"additional","affiliation":[{"name":"Department of Zoology, University of Oxford, Oxford, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James","family":"Bray","sequence":"additional","affiliation":[{"name":"Department of Zoology, University of Oxford, Oxford, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6321-5138","authenticated-orcid":false,"given":"Martin C. 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