{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,26]],"date-time":"2026-03-26T14:15:01Z","timestamp":1774534501379,"version":"3.50.1"},"reference-count":64,"publisher":"American Society for Microbiology","issue":"3","license":[{"start":{"date-parts":[[2017,5,24]],"date-time":"2017-05-24T00:00:00Z","timestamp":1495584000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2017,6,28]],"date-time":"2017-06-28T00:00:00Z","timestamp":1498608000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"funder":[{"name":"Korean Ministry of Environment","award":["2016001350004"],"award-info":[{"award-number":["2016001350004"]}]},{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["NRF-2013R1A1A2012270"],"award-info":[{"award-number":["NRF-2013R1A1A2012270"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["mSphere"],"published-print":{"date-parts":[[2017,6,28]]},"abstract":"<jats:p>\n            In the present study, plasmid pAC3 isolated from a highly fluoroquinolone-resistant isolate of\n            <jats:italic>Aeromonas<\/jats:italic>\n            species was sequenced and found to contain two fluoroquinolone resistance genes,\n            <jats:italic>aac<\/jats:italic>\n            (\n            <jats:italic>6\u2032<\/jats:italic>\n            )-\n            <jats:italic>Ib-cr<\/jats:italic>\n            and\n            <jats:italic>qnrS2<\/jats:italic>\n            . Comparative analyses of plasmid pAC3 and other\n            <jats:italic>Aeromonas<\/jats:italic>\n            sp. IncU-type plasmids revealed a mobile insertion cassette element with a unique structure containing a\n            <jats:italic>qnrS2<\/jats:italic>\n            gene and a typical miniature inverted-repeat transposable element (MITE) structure. This study also revealed that this MITE sequence appears in other\n            <jats:italic>Aeromonas<\/jats:italic>\n            species plasmids and chromosomes. Our results also demonstrate that the fluoroquinolone-dependent expression of\n            <jats:italic>qnrS2<\/jats:italic>\n            is associated with\n            <jats:italic>rsd<\/jats:italic>\n            in\n            <jats:named-content content-type=\"genus-species\">E. coli<\/jats:named-content>\n            DH5\u03b1 harboring plasmid pAC3. Our findings suggest that the mobile element may play an important role in\n            <jats:italic>qnrS2<\/jats:italic>\n            dissemination and that\n            <jats:italic>Aeromonas<\/jats:italic>\n            species constitute an important reservoir of fluoroquinolone resistance determinants in the environment.\n          <\/jats:p>","DOI":"10.1128\/msphere.00203-17","type":"journal-article","created":{"date-parts":[[2017,5,25]],"date-time":"2017-05-25T00:35:17Z","timestamp":1495672517000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":6,"title":["Unique Features of\n            <i>Aeromonas<\/i>\n            Plasmid pAC3 and Expression of the Plasmid-Mediated Quinolone Resistance Genes"],"prefix":"10.1128","volume":"2","author":[{"given":"Dae-Wi","family":"Kim","sequence":"first","affiliation":[{"name":"Department of Systems Biotechnology and Center for Antibiotic Resistome, Chung-Ang University, Anseong, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cung Nawl","family":"Thawng","sequence":"additional","affiliation":[{"name":"Department of Systems Biotechnology and Center for Antibiotic Resistome, Chung-Ang University, Anseong, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5660-7122","authenticated-orcid":false,"given":"Sang Hee","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences, National Leading Research Laboratory of Drug Resistance Proteomics, Myongji University, Yongin, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chang-Jun","family":"Cha","sequence":"additional","affiliation":[{"name":"Department of Systems Biotechnology and Center for Antibiotic Resistome, Chung-Ang University, Anseong, Republic of 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