{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T18:43:25Z","timestamp":1785437005966,"version":"3.56.0"},"reference-count":5,"publisher":"American Society for Microbiology","issue":"6","license":[{"start":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T00:00:00Z","timestamp":1782777600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T00:00:00Z","timestamp":1782777600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["mSphere"],"published-print":{"date-parts":[[2026,6,30]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title\/>\n                    <jats:p>\n                      Xin-Ru Wang works in tick biology and intracellular bacterial pathogenesis. In this mSphere of Influence article, she reflects on how \u201cGut microbiota of the tick vector\n                      <jats:italic toggle=\"yes\">Ixodes scapularis<\/jats:italic>\n                      modulate colonization of the Lyme disease spirochete\u201d by Narasimhan et al. (2014) reshaped her understanding of vector competence by placing pathogen colonization within the ecological context of the tick microbiome. Her laboratory studies\n                      <jats:italic toggle=\"yes\">Rickettsia<\/jats:italic>\n                      -tick cell interactions, including autophagy, apoptosis, and innate immune signaling. Here, she examines how this ecological framework extends to the intracellular level, where pathogenic\n                      <jats:italic toggle=\"yes\">Rickettsia<\/jats:italic>\n                      may encounter cellular environments already shaped by resident endosymbionts.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1128\/msphere.00213-26","type":"journal-article","created":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T13:02:55Z","timestamp":1779282175000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":0,"title":["mSphere of Influence: How a gut microbiota study reshaped my thinking on tick-borne pathogens"],"prefix":"10.1128","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9692-865X","authenticated-orcid":true,"given":"Xin-Ru","family":"Wang","sequence":"first","affiliation":[{"id":[{"id":"https:\/\/ror.org\/040kfrw16","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Microbiology and Immunology, Upstate Medical University","place":["Syracuse, USA"]},{"id":[{"id":"https:\/\/ror.org\/040kfrw16","id-type":"ROR","asserted-by":"publisher"}],"name":"SUNY Center for Vector-Borne Diseases, Upstate Medical University","place":["Syracuse, USA"]},{"id":[{"id":"https:\/\/ror.org\/040kfrw16","id-type":"ROR","asserted-by":"publisher"}],"name":"Institute for Global Health and Translational Sciences, Upstate Medical University","place":["Syracuse, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_1_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2013.12.001"},{"key":"e_1_3_1_3_2","doi-asserted-by":"publisher","DOI":"10.1038\/nri3535"},{"key":"e_1_3_1_4_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1613422114"},{"key":"e_1_3_1_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2018.04.038"},{"key":"e_1_3_1_6_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2030243"}],"container-title":["mSphere"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/msphere.00213-26","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/msphere.00213-26","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T13:02:31Z","timestamp":1783688551000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/msphere.00213-26"}},"subtitle":[],"editor":[{"given":"Ira J.","family":"Blader","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2026,6,30]]},"references-count":5,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2026,6,30]]}},"alternative-id":["10.1128\/msphere.00213-26"],"URL":"https:\/\/doi.org\/10.1128\/msphere.00213-26","relation":{},"ISSN":["2379-5042"],"issn-type":[{"value":"2379-5042","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6,30]]},"assertion":[{"value":"2026-05-20","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e00213-26"}}