{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T01:35:52Z","timestamp":1791423352003,"version":"4.3.3"},"reference-count":28,"publisher":"American Society for Microbiology","issue":"4","license":[{"start":{"date-parts":[[2020,7,22]],"date-time":"2020-07-22T00:00:00Z","timestamp":1595376000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2020,8,26]],"date-time":"2020-08-26T00:00:00Z","timestamp":1598400000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"funder":[{"DOI":"10.13039\/100000865","name":"Bill and Melinda Gates Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000865","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004107","name":"Sabin Vaccine Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004107","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["mSphere"],"published-print":{"date-parts":[[2020,8,26]]},"abstract":"<jats:p>\n                    The emergence of XDR\n                    <jats:italic>Salmonella<\/jats:italic>\n                    Typhi in Pakistan has left azithromycin as the only viable oral treatment option. Here, we report the detection of an azithromycin resistance-associated mutation in one\n                    <jats:italic>S.<\/jats:italic>\n                    Typhi isolate. This finding is important because any possible spread of azithromycin resistance in\n                    <jats:italic>S.<\/jats:italic>\n                    Typhi isolates would make it nearly impossible to treat in outpatient settings due to the need of injectable antibiotics. Our findings also signify the importance of introduction of typhoid conjugate vaccine in regions of endemicity such as Pakistan.\n                  <\/jats:p>","DOI":"10.1128\/msphere.00215-20","type":"journal-article","created":{"date-parts":[[2020,7,22]],"date-time":"2020-07-22T09:39:26Z","timestamp":1595410766000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":51,"title":["A Race against Time: Reduced Azithromycin Susceptibility in\n                    <i>Salmonella enterica<\/i>\n                    Serovar Typhi in Pakistan"],"prefix":"10.1128","volume":"5","author":[{"given":"Junaid","family":"Iqbal","sequence":"first","affiliation":[{"name":"Department of Paediatrics and Child Health, Aga Khan University, Karachi, Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irum F.","family":"Dehraj","sequence":"additional","affiliation":[{"name":"Department of Paediatrics and Child Health, Aga Khan University, Karachi, Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Megan E.","family":"Carey","sequence":"additional","affiliation":[{"name":"Cambridge Institute of Therapeutic Immunology and Infectious Disease, Department of Medicine, University of Cambridge, Cambridge, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zoe A.","family":"Dyson","sequence":"additional","affiliation":[{"name":"Cambridge Institute of Therapeutic Immunology and Infectious Disease, Department of Medicine, University of Cambridge, Cambridge, United Kingdom"},{"name":"Department of Infectious Diseases, Central Clinical School, Monash University, Melbourne, Victoria, Australia"},{"name":"London School of Hygiene and Tropical Medicine, London, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Denise","family":"Garrett","sequence":"additional","affiliation":[{"name":"Sabin Vaccine Institute, Washington, DC, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessica C.","family":"Seidman","sequence":"additional","affiliation":[{"name":"Sabin Vaccine Institute, Washington, DC, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Furqan","family":"Kabir","sequence":"additional","affiliation":[{"name":"Department of Paediatrics and Child Health, Aga Khan University, Karachi, Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Senjuti","family":"Saha","sequence":"additional","affiliation":[{"name":"Child Health Research Foundation, Dhaka, Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen","family":"Baker","sequence":"additional","affiliation":[{"name":"Cambridge Institute of Therapeutic Immunology and Infectious Disease, Department of Medicine, University of Cambridge, Cambridge, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4173-680X","authenticated-orcid":false,"given":"Farah N.","family":"Qamar","sequence":"additional","affiliation":[{"name":"Department of Paediatrics and Child Health, Aga Khan University, Karachi, Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_1_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(18)30685-6"},{"key":"e_1_3_1_3_2","doi-asserted-by":"publisher","DOI":"10.1093\/clinids\/7.2.244"},{"key":"e_1_3_1_4_2","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciy846"},{"key":"e_1_3_1_5_2","doi-asserted-by":"publisher","DOI":"10.1099\/00222615-44-5-317"},{"key":"e_1_3_1_6_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0006779"},{"key":"e_1_3_1_7_2","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciy877"},{"key":"e_1_3_1_8_2","doi-asserted-by":"publisher","DOI":"10.1128\/mBio.00105-18"},{"key":"e_1_3_1_9_2","doi-asserted-by":"publisher","DOI":"10.1128\/mBio.00482-18"},{"key":"e_1_3_1_10_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0007868"},{"key":"e_1_3_1_11_2","volume-title":"Performance standards for antimicrobial susceptibility testing","author":"CLSI","year":"2018","unstructured":"CLSI. 2018. 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Pakistan becomes first country to introduce new typhoid vaccine into routine immunization program p 10\u201312. 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