{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T17:27:15Z","timestamp":1785432435115,"version":"3.56.0"},"reference-count":39,"publisher":"American Society for Microbiology","issue":"6","license":[{"start":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T00:00:00Z","timestamp":1782777600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T00:00:00Z","timestamp":1782777600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"funder":[{"DOI":"10.13039\/100012394","name":"Robert J. Kleberg, Jr. and Helen C. 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Without identifying compounds altered by disease, it is difficult to uncover the responsible mechanism(s) and develop effective diagnostic tools. To understand how viral pathogens may alter the human volatilome, we collected saliva from healthy patients and patients with confirmed viral infections. Using headspace GC-MS analyses, we examined associations between 85 salivary volatiles and specific viral pathogens. Twenty-eight salivary volatiles were up- or downregulated (in relation to the healthy condition) by infection with one or more viral pathogens. Further examination indicated that salivary volatiles encode some level of viral specificity. In particular, SARS-CoV-2 infection produced a unique volatile pattern differing from several other common viral respiratory infections.<\/jats:p>\n                    <jats:sec>\n                      <jats:title>IMPORTANCE<\/jats:title>\n                      <jats:p>This research examined alterations of the salivary volatilome caused by confirmed respiratory virus infections. Results indicate that the salivary volatilome may specify the offending pathogen for improved clinical outcomes.<\/jats:p>\n                    <\/jats:sec>\n                  <\/jats:sec>","DOI":"10.1128\/msphere.00222-26","type":"journal-article","created":{"date-parts":[[2026,5,11]],"date-time":"2026-05-11T13:00:19Z","timestamp":1778504419000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":0,"title":["Viral infections alter the human salivary volatilome"],"prefix":"10.1128","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8637-8562","authenticated-orcid":true,"given":"Bruce A.","family":"Kimball","sequence":"first","affiliation":[{"id":[{"id":"https:\/\/ror.org\/01mdfdm06","id-type":"ROR","asserted-by":"publisher"}],"name":"Monell Chemical Senses Center","place":["Philadelphia, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gary K.","family":"Beauchamp","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/01mdfdm06","id-type":"ROR","asserted-by":"publisher"}],"name":"Monell Chemical Senses Center","place":["Philadelphia, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olivia F.","family":"Taylor","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/01z7r7q48","id-type":"ROR","asserted-by":"publisher"}],"name":"Children\u2019s Hospital of Philadelphia","place":["Philadelphia, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan E.","family":"Coffin","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/01z7r7q48","id-type":"ROR","asserted-by":"publisher"}],"name":"Children\u2019s Hospital of Philadelphia","place":["Philadelphia, USA"]},{"id":[{"id":"https:\/\/ror.org\/00b30xv10","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Pediatrics, Perelman School of Medicine, University of Pennsylvania","place":["Philadelphia, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frances B.","family":"Balamuth","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/01z7r7q48","id-type":"ROR","asserted-by":"publisher"}],"name":"Children\u2019s Hospital of Philadelphia","place":["Philadelphia, USA"]},{"id":[{"id":"https:\/\/ror.org\/00b30xv10","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Pediatrics, Perelman School of Medicine, University of Pennsylvania","place":["Philadelphia, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juliana","family":"Jones","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/01mdfdm06","id-type":"ROR","asserted-by":"publisher"}],"name":"Monell Chemical Senses Center","place":["Philadelphia, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8395-8537","authenticated-orcid":true,"given":"Audrey R.","family":"John","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/01z7r7q48","id-type":"ROR","asserted-by":"publisher"}],"name":"Children\u2019s Hospital of Philadelphia","place":["Philadelphia, USA"]},{"id":[{"id":"https:\/\/ror.org\/00b30xv10","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Pediatrics, Perelman School of Medicine, University of Pennsylvania","place":["Philadelphia, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Virginia A.","family":"Stallings","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/01z7r7q48","id-type":"ROR","asserted-by":"publisher"}],"name":"Children\u2019s Hospital of Philadelphia","place":["Philadelphia, USA"]},{"id":[{"id":"https:\/\/ror.org\/00b30xv10","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Pediatrics, Perelman School of Medicine, University of Pennsylvania","place":["Philadelphia, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_5_2_2","doi-asserted-by":"publisher","DOI":"10.1136\/pgmj.52.605.136"},{"key":"e_1_3_5_3_2","doi-asserted-by":"publisher","DOI":"10.1093\/jb\/mvr090"},{"key":"e_1_3_5_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.microc.2025.113700"},{"key":"e_1_3_5_5_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-021-81086-x"},{"key":"e_1_3_5_6_2","first-page":"300","article-title":"Smelling the diagnosis: a review on the use of scent in diagnosing disease","volume":"71","author":"Bijland LR","year":"2013","unstructured":"Bijland LR, Bomers MK, Smulders YM. 2013. 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