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To date, studies aimed at bacterial and fungal contamination of space vessels have highlighted species compositions biased toward hardy, persistent organisms capable of withstanding harsh conditions. In the current study, we assessed traits of two independent\n            <jats:named-content content-type=\"genus-species\">Aspergillus fumigatus<\/jats:named-content>\n            strains isolated from the International Space Station. Ubiquitously found in terrestrial soil and atmospheric environments,\n            <jats:named-content content-type=\"genus-species\">A. fumigatus<\/jats:named-content>\n            is a significant opportunistic fungal threat to human health, particularly among the immunocompromised. Using two well-known clinical isolates of\n            <jats:named-content content-type=\"genus-species\">A. fumigatus<\/jats:named-content>\n            as comparators, we found that both ISS isolates exhibited normal\n            <jats:italic>in vitro<\/jats:italic>\n            growth and chemical stress tolerance yet caused higher lethality in a vertebrate model of invasive disease. These findings substantiate the need for additional studies of physical traits and biological activities of microbes adapted to microgravity and other extreme extraterrestrial conditions.\n          <\/jats:p>","DOI":"10.1128\/msphere.00227-16","type":"journal-article","created":{"date-parts":[[2016,10,27]],"date-time":"2016-10-27T02:48:58Z","timestamp":1477536538000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":89,"title":["Characterization of Aspergillus fumigatus Isolates from Air and Surfaces of the International Space Station"],"prefix":"10.1128","volume":"1","author":[{"given":"Benjamin P.","family":"Knox","sequence":"first","affiliation":[{"name":"Microbiology Doctoral Training Program, University of Wisconsin\u2014Madison, Madison, Wisconsin, USA"},{"name":"Department of Medical Microbiology and Immunology, University of Wisconsin\u2014Madison, Madison, Wisconsin, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adriana","family":"Blachowicz","sequence":"additional","affiliation":[{"name":"Biotechnology and Planetary Protection Group, Jet Propulsion Laboratory, California Institute of Technology, Pasadena, California, USA"},{"name":"Department of Pharmacology and Pharmaceutical Sciences, School of Pharmacy, University of Southern California, Los Angeles, California, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0929-3658","authenticated-orcid":false,"given":"Jonathan M.","family":"Palmer","sequence":"additional","affiliation":[{"name":"Center for Forest Mycology Research, Northern Research Station, U.S. Forest Service, Madison, Wisconsin, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jillian","family":"Romsdahl","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Pharmaceutical Sciences, School of Pharmacy, University of Southern California, Los Angeles, California, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Huttenlocher","sequence":"additional","affiliation":[{"name":"Department of Medical Microbiology and Immunology, University of Wisconsin\u2014Madison, Madison, Wisconsin, USA"},{"name":"Department of Pediatrics, University of Wisconsin\u2014Madison, Madison, Wisconsin, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clay C. 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