{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,23]],"date-time":"2026-02-23T20:28:41Z","timestamp":1771878521445,"version":"3.50.1"},"reference-count":22,"publisher":"American Society for Microbiology","issue":"4","license":[{"start":{"date-parts":[[2018,8,22]],"date-time":"2018-08-22T00:00:00Z","timestamp":1534896000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2018,8,29]],"date-time":"2018-08-29T00:00:00Z","timestamp":1535500800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"funder":[{"DOI":"10.13039\/501100001665","name":"Agence Nationale de la Recherche","doi-asserted-by":"publisher","award":["NR-10-LABX-62-IBEID"],"award-info":[{"award-number":["NR-10-LABX-62-IBEID"]}],"id":[{"id":"10.13039\/501100001665","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003130","name":"Fonds Wetenschappelijk Onderzoek","doi-asserted-by":"publisher","award":["V401816N"],"award-info":[{"award-number":["V401816N"]}],"id":[{"id":"10.13039\/501100003130","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["mSphere"],"published-print":{"date-parts":[[2018,8,29]]},"abstract":"<jats:p>\n            Because of its global reemergence and unusual morbidities associated with infection, the chikungunya virus (CHIKV) has become a substantial public health problem. However, no antivirals are currently available to treat CHIKV infections. If antiviral drugs will prove to be efficient to treat CHIKV-infected patients, it will be essential to understand if drug-resistant viruses can be transmitted from one human to another by the mosquito. We therefore orally infected\n            <jats:italic>Aedes<\/jats:italic>\n            mosquitoes with drug-resistant CHIKV variants and determined the replication and transmission levels. One of the antiviral drug-resistant CHIKV variants could efficiently replicate and disseminate in both laboratory and field-collected mosquitoes. In addition, this variant retained its drug-resistant genotype in the saliva. In contrast, the other drug-resistant variant was markedly attenuated in mosquitoes. Our results illustrate that extra caution for drug resistance should be considered when developing an antiarbovirus antiviral in order to minimize the risk of spreading drug resistance by mosquitoes.\n          <\/jats:p>","DOI":"10.1128\/msphere.00230-18","type":"journal-article","created":{"date-parts":[[2018,8,21]],"date-time":"2018-08-21T09:25:38Z","timestamp":1534843538000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":10,"title":["Differential Transmission of Antiviral Drug-Resistant Chikungunya Viruses by\n            <i>Aedes<\/i>\n            Mosquitoes"],"prefix":"10.1128","volume":"3","author":[{"given":"Leen","family":"Delang","sequence":"first","affiliation":[{"name":"Department of Microbiology and Immunology, Rega Institute for Medical Research, Laboratory of Virology and Chemotherapy, KU Leuven-University of Leuven, Leuven, Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pei-Shi","family":"Yen","sequence":"additional","affiliation":[{"name":"Laboratory of Arboviruses and Insect Vectors, Institut Pasteur, Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas","family":"Vallet","sequence":"additional","affiliation":[{"name":"Viral Populations and Pathogenesis Unit, Centre National de la Recherche Scientifique UMR 3569, Institut Pasteur, Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marie","family":"Vazeille","sequence":"additional","affiliation":[{"name":"Laboratory of Arboviruses and Insect Vectors, Institut Pasteur, Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4400-771X","authenticated-orcid":false,"given":"Marco","family":"Vignuzzi","sequence":"additional","affiliation":[{"name":"Viral Populations and Pathogenesis Unit, Centre National de la Recherche 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