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Due to the high prevalences of both anti-\n            <jats:named-content content-type=\"genus-species\">C.\u00a0trachomatis<\/jats:named-content>\n            and anti-\n            <jats:named-content content-type=\"genus-species\">C.\u00a0pneumoniae<\/jats:named-content>\n            antibodies in human populations, species-specific serology is unreliable. Therefore, novel specific and simple assays for chlamydial serology are urgently needed. Conventional antigens are problematic due to extensive cross-reactivity within\n            <jats:italic>Chlamydia<\/jats:italic>\n            spp. Using accurate B cell epitope prediction and a robust peptide ELISA methodology developed in our laboratory, we identified immunodominant\n            <jats:named-content content-type=\"genus-species\">C.\u00a0trachomatis<\/jats:named-content>\n            B cell epitopes by screening performed with sera from\n            <jats:named-content content-type=\"genus-species\">C.\u00a0trachomatis<\/jats:named-content>\n            -infected women. We discovered 38 novel human host-dependent antigens from 20 immunodominant\n            <jats:named-content content-type=\"genus-species\">C.\u00a0trachomatis<\/jats:named-content>\n            proteins, in addition to confirming 10 host-independent mouse serum peptide antigens that had been identified previously. This extended set of highly specific\n            <jats:named-content content-type=\"genus-species\">C.\u00a0trachomatis<\/jats:named-content>\n            peptide antigens can be used in simple ELISA or multiplexed microarray formats and will provide high specificity and sensitivity to human\n            <jats:italic>C.\u00a0trachomatis<\/jats:italic>\n            serodiagnosis.\n          <\/jats:p>","DOI":"10.1128\/msphere.00246-18","type":"journal-article","created":{"date-parts":[[2018,7,31]],"date-time":"2018-07-31T10:02:42Z","timestamp":1533031362000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":17,"title":["Discovery of Human-Specific Immunodominant\n            <i>Chlamydia trachomatis<\/i>\n            B Cell Epitopes"],"prefix":"10.1128","volume":"3","author":[{"given":"K. Shamsur","family":"Rahman","sequence":"first","affiliation":[{"name":"Department of Pathobiology, College of Veterinary Medicine, Auburn University, Auburn, Alabama, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toni","family":"Darville","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ali N.","family":"Russell","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherine M.","family":"O\u2019Connell","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harold C.","family":"Wiesenfeld","sequence":"additional","affiliation":[{"name":"Department of Obstetrics, Gynaecology and Reproductive Sciences, the University of Pittsburgh School of Medicine and the Magee-Womens Research Institute Pittsburgh, Pittsburgh, Pennsylvania, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sharon L.","family":"Hillier","sequence":"additional","affiliation":[{"name":"Department of Obstetrics, Gynaecology and Reproductive Sciences, the University of Pittsburgh School of Medicine and the Magee-Womens Research Institute Pittsburgh, Pittsburgh, Pennsylvania, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erfan U.","family":"Chowdhury","sequence":"additional","affiliation":[{"name":"Department of Pathobiology, College of Veterinary Medicine, Auburn University, Auburn, Alabama, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yen-Chen","family":"Juan","sequence":"additional","affiliation":[{"name":"Department of Pathobiology, College of Veterinary Medicine, Auburn University, Auburn, Alabama, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernhard","family":"Kaltenboeck","sequence":"additional","affiliation":[{"name":"Department of Pathobiology, College of Veterinary Medicine, Auburn University, Auburn, Alabama, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_3_2_2","first-page":"846","volume-title":"Bergey\u2019s manual of systematic bacteriology","author":"Kuo CC","year":"2011","unstructured":"Kuo CC, Stephens RS, Bavoil PM, Kaltenboeck B. 2011. 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