{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T14:12:04Z","timestamp":1790345524569,"version":"4.1.0"},"reference-count":55,"publisher":"American Society for Microbiology","issue":"4","license":[{"start":{"date-parts":[[2017,7,12]],"date-time":"2017-07-12T00:00:00Z","timestamp":1499817600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2017,8,30]],"date-time":"2017-08-30T00:00:00Z","timestamp":1504051200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"funder":[{"name":"Australian Infectious Diseases Research Centre"},{"name":"Western Australia Department of Health"},{"name":"Queensland Department of Health"},{"name":"Australian Government Research Training Program Scholarship"},{"DOI":"10.13039\/501100000923","name":"Australian Research Council","doi-asserted-by":"publisher","award":["DP120103994"],"award-info":[{"award-number":["DP120103994"]}],"id":[{"id":"10.13039\/501100000923","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["mSphere"],"published-print":{"date-parts":[[2017,8,30]]},"abstract":"<jats:p>\n                    Flaviviruses like dengue, Zika, or West Nile virus infect millions of people each year and are transmitted to humans via infected-mosquito bites. A subset of flaviviruses can only replicate in the mosquito host, and recent studies have shown that some can interfere with pathogenic flaviviruses in mosquitoes and limit the replication and transmission of the latter. The insect-specific flaviviruses (ISFs) reported here form a new\n                    <jats:italic>Anopheles<\/jats:italic>\n                    mosquito-associated clade separate from the\n                    <jats:italic>Aedes<\/jats:italic>\n                    - and\n                    <jats:italic>Culex<\/jats:italic>\n                    -associated ISF clades. The identification of distinct clades for each mosquito genus provides new insights into the evolution and ecology of flaviviruses. One of these viruses was shown to replicate in the midgut of the mosquito host and exhibit the most specialized host restriction reported to date for ISFs. Understanding this unprecedented host restriction in ISFs could help identify the mechanisms involved in the evolution of flaviviruses and their emergence as mosquito-borne pathogens.\n                  <\/jats:p>","DOI":"10.1128\/msphere.00262-17","type":"journal-article","created":{"date-parts":[[2017,7,12]],"date-time":"2017-07-12T20:40:33Z","timestamp":1499892033000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":73,"title":["A New Clade of Insect-Specific Flaviviruses from Australian\n                    <i>Anopheles<\/i>\n                    Mosquitoes Displays Species-Specific Host Restriction"],"prefix":"10.1128","volume":"2","author":[{"given":"Agathe M. G.","family":"Colmant","sequence":"first","affiliation":[{"name":"School of Chemistry and Molecular Biosciences, The University of Queensland, St. Lucia, Queensland, Australia"},{"name":"Australian Infectious Diseases Research Centre (AIDRC), The University of Queensland, St. Lucia, Queensland, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jody","family":"Hobson-Peters","sequence":"additional","affiliation":[{"name":"School of Chemistry and Molecular Biosciences, The University of Queensland, St. Lucia, Queensland, Australia"},{"name":"Australian Infectious Diseases Research Centre (AIDRC), The University of Queensland, St. Lucia, Queensland, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helle","family":"Bielefeldt-Ohmann","sequence":"additional","affiliation":[{"name":"School of Chemistry and Molecular Biosciences, The University of Queensland, St. Lucia, Queensland, Australia"},{"name":"Australian Infectious Diseases Research Centre (AIDRC), The University of Queensland, St. Lucia, Queensland, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew F.","family":"van den Hurk","sequence":"additional","affiliation":[{"name":"Public Health Virology, Forensic and Scientific Services, Department of Health, Coopers Plains, Queensland, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sonja","family":"Hall-Mendelin","sequence":"additional","affiliation":[{"name":"Public Health Virology, Forensic and Scientific Services, Department of Health, Coopers Plains, Queensland, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weng Kong","family":"Chow","sequence":"additional","affiliation":[{"name":"Australian Army Malaria Institute, Gallipoli Barracks, Enoggera, Queensland, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheryl A.","family":"Johansen","sequence":"additional","affiliation":[{"name":"School of Pathology and Laboratory Medicine, The University of Western Australia, Nedlands, Western Australia, Australia"},{"name":"PathWest Laboratory Medicine WA, Nedlands, Western Australia, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jelke","family":"Fros","sequence":"additional","affiliation":[{"name":"Nuffield Department of Medicine, University of Oxford, Oxford, England, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Simmonds","sequence":"additional","affiliation":[{"name":"Nuffield Department of Medicine, University of Oxford, Oxford, England, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Watterson","sequence":"additional","affiliation":[{"name":"School of Chemistry and Molecular Biosciences, The University of Queensland, St. Lucia, Queensland, Australia"},{"name":"Australian Infectious Diseases Research Centre (AIDRC), The University of Queensland, St. Lucia, Queensland, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chris","family":"Cazier","sequence":"additional","affiliation":[{"name":"Technical Services, Biosciences Division, Faculty of Health, Queensland University of Technology, Gardens Point Campus, Brisbane, Queensland, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kayvan","family":"Etebari","sequence":"additional","affiliation":[{"name":"Australian Infectious Diseases Research Centre (AIDRC), The University of Queensland, St. Lucia, Queensland, Australia"},{"name":"School of the Biological Sciences, The University of Queensland, St. Lucia, Queensland, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sassan","family":"Asgari","sequence":"additional","affiliation":[{"name":"Australian Infectious Diseases Research Centre (AIDRC), The University of Queensland, St. Lucia, Queensland, Australia"},{"name":"School of the Biological Sciences, The University of Queensland, St. Lucia, Queensland, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin L.","family":"Schulz","sequence":"additional","affiliation":[{"name":"School of Chemistry and Molecular Biosciences, The University of Queensland, St. Lucia, Queensland, Australia"},{"name":"Australian Infectious Diseases Research Centre (AIDRC), The University of Queensland, St. Lucia, Queensland, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nigel","family":"Beebe","sequence":"additional","affiliation":[{"name":"School of the Biological Sciences, The University of Queensland, St. Lucia, Queensland, Australia"},{"name":"CSIRO, Dutton Park, Queensland, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura J.","family":"Vet","sequence":"additional","affiliation":[{"name":"School of Chemistry and Molecular Biosciences, The University of Queensland, St. Lucia, Queensland, Australia"},{"name":"Australian Infectious Diseases Research Centre (AIDRC), The University of Queensland, St. Lucia, Queensland, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1657-8558","authenticated-orcid":false,"given":"Thisun B. H.","family":"Piyasena","sequence":"additional","affiliation":[{"name":"School of Chemistry and Molecular Biosciences, The University of Queensland, St. Lucia, Queensland, Australia"},{"name":"Australian Infectious Diseases Research Centre (AIDRC), The University of Queensland, St. Lucia, Queensland, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong-Duyen","family":"Nguyen","sequence":"additional","affiliation":[{"name":"School of Chemistry and Molecular Biosciences, The University of Queensland, St. Lucia, Queensland, Australia"},{"name":"Australian Infectious Diseases Research Centre (AIDRC), The University of Queensland, St. Lucia, Queensland, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ross T.","family":"Barnard","sequence":"additional","affiliation":[{"name":"School of Chemistry and Molecular Biosciences, The University of Queensland, St. Lucia, Queensland, Australia"},{"name":"Australian Infectious Diseases Research Centre (AIDRC), The University of Queensland, St. Lucia, Queensland, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roy A.","family":"Hall","sequence":"additional","affiliation":[{"name":"School of Chemistry and Molecular Biosciences, The University of Queensland, St. Lucia, Queensland, Australia"},{"name":"Australian Infectious Diseases Research Centre (AIDRC), The University of Queensland, St. Lucia, Queensland, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF02633958"},{"key":"e_1_3_2_3_2","first-page":"73","volume-title":"Encephalitis","author":"Perng G-C","year":"2013","unstructured":"Perng G-C Chen W-J . 2013. Arboviral encephalitis, p 73\u201394. InTkachevS (ed), Encephalitis. InTech, Rijeka, Croatia."},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1159\/000149642"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.mi.44.100190.003245"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0065-3527(03)60006-0"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.18.4.608-637.2005"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.3390\/v7041927"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.2011.10-0474"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.virol.2012.02.016"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1673\/031.007.5501"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.virol.2016.07.031"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1111\/1755-0998.12584"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13071-016-1683-2"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0056534"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.virol.2015.07.021"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.01114-12"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1502036112"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature20167"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.02036-15"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.72.1.73-83.1998"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1089\/vbz.2007.0206"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0923-2516(07)80011-2"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1099\/jgv.0.000430"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.virol.2009.12.033"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0006282"},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0003629"},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0000856"},{"key":"e_1_3_2_29_2","doi-asserted-by":"publisher","DOI":"10.1099\/vir.0.79850-0"},{"key":"e_1_3_2_30_2","doi-asserted-by":"publisher","DOI":"10.1186\/1743-422X-6-93"},{"key":"e_1_3_2_31_2","doi-asserted-by":"publisher","DOI":"10.1093\/ve\/vew035"},{"key":"e_1_3_2_32_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-61779-037-9_1"},{"key":"e_1_3_2_33_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1000502"},{"key":"e_1_3_2_34_2","doi-asserted-by":"publisher","DOI":"10.4137\/EBO.S40740"},{"key":"e_1_3_2_35_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0080720"},{"key":"e_1_3_2_36_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.00601-10"},{"key":"e_1_3_2_37_2","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2148-9-298"},{"key":"e_1_3_2_38_2","doi-asserted-by":"publisher","DOI":"10.11646\/zootaxa.1668.1.28"},{"key":"e_1_3_2_39_2","doi-asserted-by":"publisher","DOI":"10.2987\/09-5908.1"},{"key":"e_1_3_2_40_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0000671"},{"key":"e_1_3_2_41_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1004256"},{"key":"e_1_3_2_42_2","doi-asserted-by":"publisher","DOI":"10.1098\/rstb.2008.0168"},{"key":"e_1_3_2_43_2","doi-asserted-by":"publisher","DOI":"10.3390\/v7020820"},{"key":"e_1_3_2_44_2","doi-asserted-by":"publisher","DOI":"10.1038\/nmicrobiol.2017.25"},{"key":"e_1_3_2_45_2","doi-asserted-by":"publisher","DOI":"10.1603\/0022-2585-39.5.786"},{"key":"e_1_3_2_46_2","doi-asserted-by":"publisher","DOI":"10.1186\/1743-422X-5-16"},{"key":"e_1_3_2_47_2","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.1995.53.478"},{"key":"e_1_3_2_48_2","doi-asserted-by":"publisher","DOI":"10.1080\/10635150390235520"},{"key":"e_1_3_2_49_2","doi-asserted-by":"publisher","DOI":"10.1016\/0022-2836(84)90192-X"},{"key":"e_1_3_2_50_2","doi-asserted-by":"publisher","DOI":"10.1186\/1756-0500-5-50"},{"key":"e_1_3_2_51_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF01194061"},{"key":"e_1_3_2_52_2","doi-asserted-by":"publisher","DOI":"10.1016\/0035-9203(72)90068-5"},{"key":"e_1_3_2_53_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2583.1999.83127.x"},{"key":"e_1_3_2_54_2","doi-asserted-by":"publisher","DOI":"10.1002\/rcm.6806"},{"key":"e_1_3_2_55_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.03144-12"},{"key":"e_1_3_2_56_2","doi-asserted-by":"publisher","DOI":"10.1038\/icb.1988.6"}],"container-title":["mSphere"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/mSphere.00262-17","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/mSphere.00262-17","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,7]],"date-time":"2022-03-07T22:57:03Z","timestamp":1646693823000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/mSphere.00262-17"}},"subtitle":[],"editor":[{"given":"James M.","family":"Pipas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2017,8,30]]},"references-count":55,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2017,8,30]]}},"alternative-id":["10.1128\/mSphere.00262-17"],"URL":"https:\/\/doi.org\/10.1128\/msphere.00262-17","relation":{},"ISSN":["2379-5042"],"issn-type":[{"value":"2379-5042","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,8,30]]},"assertion":[{"value":"2017-06-09","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2017-06-13","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2017-07-12","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e00262-17"}}