{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T06:19:24Z","timestamp":1790662764913,"version":"4.1.0"},"reference-count":28,"publisher":"American Society for Microbiology","issue":"2","license":[{"start":{"date-parts":[[2020,4,22]],"date-time":"2020-04-22T00:00:00Z","timestamp":1587513600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2020,4,29]],"date-time":"2020-04-29T00:00:00Z","timestamp":1588118400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"funder":[{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["MO 846\/7"],"award-info":[{"award-number":["MO 846\/7"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["mSphere"],"published-print":{"date-parts":[[2020,4,29]]},"abstract":"<jats:p>\n            <jats:named-content content-type=\"genus-species\">Candida auris<\/jats:named-content>\n            is a recently emerged pathogenic yeast that within a few years after its initial description has spread all over the globe.\n            <jats:named-content content-type=\"genus-species\">C. auris<\/jats:named-content>\n            is a major concern for human health, because it can cause life-threatening systemic infections, is easily transmissible, and is difficult to eradicate from hospital environments. Furthermore,\n            <jats:named-content content-type=\"genus-species\">C. auris<\/jats:named-content>\n            is highly drug resistant, especially against the widely used antifungal drug fluconazole. Mutations in the drug target and high activity of efflux pumps are associated with azole resistance, but it is not known how drug resistance genes are regulated in\n            <jats:named-content content-type=\"genus-species\">C. auris<\/jats:named-content>\n            . We have investigated the potential role of several candidate transcriptional regulators in the intrinsic fluconazole resistance of\n            <jats:named-content content-type=\"genus-species\">C. auris<\/jats:named-content>\n            and identified a transcription factor that contributes to the high resistance to fluconazole and voriconazole of two\n            <jats:named-content content-type=\"genus-species\">C. auris<\/jats:named-content>\n            strains from different genetic clades, thereby providing insight into the molecular basis of drug resistance of this medically important yeast.\n          <\/jats:p>","DOI":"10.1128\/msphere.00279-20","type":"journal-article","created":{"date-parts":[[2020,4,21]],"date-time":"2020-04-21T13:38:08Z","timestamp":1587476288000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":55,"title":["A Zinc Cluster Transcription Factor Contributes to the Intrinsic Fluconazole 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