{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T07:09:33Z","timestamp":1790665773550,"version":"4.1.0"},"reference-count":26,"publisher":"American Society for Microbiology","issue":"3","license":[{"start":{"date-parts":[[2019,6,19]],"date-time":"2019-06-19T00:00:00Z","timestamp":1560902400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2019,6,26]],"date-time":"2019-06-26T00:00:00Z","timestamp":1561507200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["mSphere"],"published-print":{"date-parts":[[2019,6,26]]},"abstract":"<jats:p>\n            Inhalational anthrax caused by\n            <jats:named-content content-type=\"genus-species\">Bacillus anthracis<\/jats:named-content>\n            , a spore-forming Gram-positive bacterium, is a highly lethal infection. Antibodies targeting the protective antigen (PA) binding component of the toxins have recently been authorized as an adjunct to antibiotics, although no conclusive evidence demonstrates that anthrax antitoxin therapy has any significant benefit. We discuss here the rational basis of anti-PA development regarding the pathogenesis of the disease.\n          <\/jats:p>","DOI":"10.1128\/msphere.00282-19","type":"journal-article","created":{"date-parts":[[2019,6,18]],"date-time":"2019-06-18T11:34:51Z","timestamp":1560857691000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":14,"title":["Questionable Efficacy of Therapeutic Antibodies in the Treatment of Anthrax"],"prefix":"10.1128","volume":"4","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4542-2421","authenticated-orcid":false,"given":"Jean-Nicolas","family":"Tournier","sequence":"first","affiliation":[{"name":"Institut de Recherche Biom\u00e9dicale des Arm\u00e9es, Bacteriology, Anti-infectious Biotherapies, and Immunity Unit, Br\u00e9tigny-sur-Orge, France"},{"name":"Institut Pasteur, Viral Genomics and Vaccination Unit, CNRS UMR-3569, Paris, France"},{"name":"National Reference Center for Anthrax (CNR-LE Charbon), Br\u00e9tigny-sur-Orge, France"},{"name":"Ecole du Val-de-Gr\u00e2ce, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cl\u00e9mence","family":"Rougeaux","sequence":"additional","affiliation":[{"name":"Institut de Recherche Biom\u00e9dicale des Arm\u00e9es, Bacteriology, Anti-infectious Biotherapies, and Immunity Unit, Br\u00e9tigny-sur-Orge, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3632-2146","authenticated-orcid":false,"given":"Fabrice V.","family":"Biot","sequence":"additional","affiliation":[{"name":"Institut de Recherche Biom\u00e9dicale des Arm\u00e9es, Bacteriology, Anti-infectious Biotherapies, and Immunity Unit, Br\u00e9tigny-sur-Orge, France"},{"name":"National Reference Center for Anthrax (CNR-LE Charbon), Br\u00e9tigny-sur-Orge, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierre L.","family":"Goossens","sequence":"additional","affiliation":[{"name":"Institut de Recherche Biom\u00e9dicale des Arm\u00e9es, Bacteriology, Anti-infectious Biotherapies, and Immunity Unit, Br\u00e9tigny-sur-Orge, France"},{"name":"Institut Pasteur, Yersinia Unit, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_1_2_2","doi-asserted-by":"publisher","DOI":"10.3201\/eid0706.010604"},{"key":"e_1_3_1_3_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-144-4-200602210-00009"},{"key":"e_1_3_1_4_2","volume-title":"Public law 108-276","author":"Project BioShield Act","year":"2004","unstructured":"Project BioShield Act. 2004. Public law 108-276. 108th Congress, Washington, DC. https:\/\/www.congress.gov\/108\/plaws\/publ276\/PLAW-108publ276.pdf."},{"key":"e_1_3_1_5_2","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/cix097"},{"key":"e_1_3_1_6_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0182879"},{"key":"e_1_3_1_7_2","doi-asserted-by":"publisher","DOI":"10.1097\/QCO.0000000000000446"},{"key":"e_1_3_1_8_2","doi-asserted-by":"publisher","DOI":"10.3201\/eid2301.160608"},{"key":"e_1_3_1_9_2","doi-asserted-by":"publisher","DOI":"10.1089\/hs.2015.0032"},{"key":"e_1_3_1_10_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-micro-091014-104523"},{"key":"e_1_3_1_11_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.aau1330"},{"key":"e_1_3_1_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0966-842X(00)01755-8"},{"key":"e_1_3_1_13_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.1.2297.16"},{"key":"e_1_3_1_14_2","doi-asserted-by":"publisher","DOI":"10.1128\/iai.65.12.5171-5175.1997"},{"key":"e_1_3_1_15_2","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2015.01122"},{"key":"e_1_3_1_16_2","doi-asserted-by":"publisher","DOI":"10.1038\/173869a0"},{"key":"e_1_3_1_17_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20172295"},{"key":"e_1_3_1_18_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature12510"},{"key":"e_1_3_1_19_2","doi-asserted-by":"publisher","DOI":"10.1038\/srep23346"},{"key":"e_1_3_1_20_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.00346-09"},{"key":"e_1_3_1_21_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01102-16"},{"key":"e_1_3_1_22_2","volume-title":"What is the thing called science? An assessment of the nature and status of science and its methods","author":"Chalmers AF","year":"1976","unstructured":"Chalmers AF. 1976. What is the thing called science? An assessment of the nature and status of science and its methods. University of Queensland Press, Saint Lucia, Australia."},{"key":"e_1_3_1_23_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.04606-14"},{"key":"e_1_3_1_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.mam.2009.07.005"},{"key":"e_1_3_1_25_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.06340-11"},{"key":"e_1_3_1_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajpath.2014.08.008"},{"key":"e_1_3_1_27_2","doi-asserted-by":"publisher","DOI":"10.1186\/s40635-015-0043-4"}],"container-title":["mSphere"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/mSphere.00282-19","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/mSphere.00282-19","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,8]],"date-time":"2022-03-08T04:19:23Z","timestamp":1646713163000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/mSphere.00282-19"}},"subtitle":[],"editor":[{"given":"Patricia A.","family":"Bradford","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2019,6,26]]},"references-count":26,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2019,6,26]]}},"alternative-id":["10.1128\/mSphere.00282-19"],"URL":"https:\/\/doi.org\/10.1128\/msphere.00282-19","relation":{},"ISSN":["2379-5042"],"issn-type":[{"value":"2379-5042","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,6,26]]},"assertion":[{"value":"2019-06-19","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e00282-19"}}