{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T20:33:46Z","timestamp":1790800426628,"version":"4.1.0"},"reference-count":28,"publisher":"American Society for Microbiology","issue":"4","license":[{"start":{"date-parts":[[2017,7,26]],"date-time":"2017-07-26T00:00:00Z","timestamp":1501027200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2017,8,30]],"date-time":"2017-08-30T00:00:00Z","timestamp":1504051200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"funder":[{"name":"Directorate of Higher Education PhD grant of the Ministry of Research, Technology and Higher Education of the Republic of Indonesia"},{"name":"Erasmus MC Foundation"},{"name":"European Union program ZIKAlliance","award":["734548"],"award-info":[{"award-number":["734548"]}]},{"name":"Reacting and La Region Languedoc Roussillon"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["mSphere"],"published-print":{"date-parts":[[2017,8,30]]},"abstract":"<jats:p>The mechanism by which ZIKV causes a range of neurological complications, especially congenital microcephaly, is not well understood. The fact that congenital microcephaly is associated with Asian lineage ZIKV strains raises the question of why this was not discovered earlier. One possible explanation is that Asian and African ZIKV strains differ in their abilities to infect cells of the CNS and to cause neurodevelopmental problems. Here, we show that Asian ZIKV strains infect and induce cell death in human neural progenitor cells\u2014which are important target cells in the development of congenital microcephaly\u2014less efficiently than African ZIKV strains. These features of Asian ZIKV strains likely contribute to their ability to cause chronic infections, often observed in congenital microcephaly cases. It is therefore likely that phenotypic differences between ZIKV strains could be, at least in part, responsible for the ability of Asian ZIKV strains to cause congenital microcephaly.<\/jats:p>","DOI":"10.1128\/msphere.00292-17","type":"journal-article","created":{"date-parts":[[2017,7,27]],"date-time":"2017-07-27T00:25:35Z","timestamp":1501115135000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":111,"title":["Phenotypic Differences between Asian and African Lineage Zika Viruses in Human Neural Progenitor Cells"],"prefix":"10.1128","volume":"2","author":[{"given":"Fatih","family":"Anfasa","sequence":"first","affiliation":[{"name":"Department of Viroscience, Erasmus MC, Rotterdam, The Netherlands"},{"name":"Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jurre Y.","family":"Siegers","sequence":"additional","affiliation":[{"name":"Department of Viroscience, Erasmus MC, Rotterdam, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark","family":"van der Kroeg","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Erasmus MC, Rotterdam, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noreen","family":"Mumtaz","sequence":"additional","affiliation":[{"name":"Department of Viroscience, Erasmus MC, Rotterdam, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V.","family":"Stalin Raj","sequence":"additional","affiliation":[{"name":"Department of Viroscience, Erasmus MC, Rotterdam, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Femke M. 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