{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,6]],"date-time":"2025-11-06T20:11:35Z","timestamp":1762459895858,"version":"3.41.2"},"reference-count":52,"publisher":"American Society for Microbiology","issue":"3","license":[{"start":{"date-parts":[[2020,6,10]],"date-time":"2020-06-10T00:00:00Z","timestamp":1591747200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2020,6,24]],"date-time":"2020-06-24T00:00:00Z","timestamp":1592956800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"funder":[{"DOI":"10.13039\/100008762","name":"Genome Canada","doi-asserted-by":"publisher","award":["8505"],"award-info":[{"award-number":["8505"]}],"id":[{"id":"10.13039\/100008762","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["mSphere"],"published-print":{"date-parts":[[2020,6,24]]},"abstract":"<jats:p>\n            <jats:italic>Salmonella<\/jats:italic>\n            species are bacteria that are a major source of foodborne disease through contamination of a diversity of foods, including meat, eggs, fruits, nuts, and vegetables. More than 2,600 different\n            <jats:named-content content-type=\"genus-species\">Salmonella enterica<\/jats:named-content>\n            serovars have been identified, and only a few of them are associated with illness in humans. Despite the fact that they are genetically closely related, there is enormous variation in the virulence of different isolates of\n            <jats:named-content content-type=\"genus-species\">Salmonella enterica<\/jats:named-content>\n            . Identification of foodborne pathogens is a lengthy process based on microbiological, biochemical, and immunological methods. Here, we worked toward new ways of integrating whole-genome sequencing (WGS) approaches into food safety practices. We used WGS to build associations between virulence and genetic diversity within 83\n            <jats:italic>Salmonella<\/jats:italic>\n            isolates representing 77 different\n            <jats:italic>Salmonella<\/jats:italic>\n            serovars. Our work demonstrates the potential of combining a genomics approach and virulence tests to improve the diagnostics and assess risk of human illness associated with specific\n            <jats:italic>Salmonella<\/jats:italic>\n            isolates.\n          <\/jats:p>","DOI":"10.1128\/msphere.00293-20","type":"journal-article","created":{"date-parts":[[2020,6,9]],"date-time":"2020-06-09T13:20:35Z","timestamp":1591708835000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":10,"title":["Combining Whole-Genome Sequencing and Multimodel Phenotyping To Identify Genetic Predictors of\n            <i>Salmonella<\/i>\n            Virulence"],"prefix":"10.1128","volume":"5","author":[{"given":"Alanna","family":"Crouse","sequence":"first","affiliation":[{"name":"McGill Research Center on Complex Traits, McGill University, Montreal, Quebec, Canada"},{"name":"Department of Human Genetics, McGill University, Montreal, Quebec, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Catherine","family":"Schramm","sequence":"additional","affiliation":[{"name":"Lady Davis Institute for Medical Research, Montreal, Quebec, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jean-Guillaume","family":"Emond-Rheault","sequence":"additional","affiliation":[{"name":"Institute for Integrative and Systems Biology, Faculty of Medicine, Universit\u00e9 Laval, Quebec City, Quebec, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adrian","family":"Herod","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, Dalhousie University, Halifax, Nova Scotia, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maud","family":"Kerhoas","sequence":"additional","affiliation":[{"name":"D\u00e9partement de Microbiologie, Infectiologie et Immunologie, Universit\u00e9 de Montr\u00e9al, Montreal, Quebec, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John","family":"Rohde","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, Dalhousie University, Halifax, Nova Scotia, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Samantha","family":"Gruenheid","sequence":"additional","affiliation":[{"name":"McGill Research Center on Complex Traits, McGill University, Montreal, Quebec, Canada"},{"name":"Department of Microbiology and Immunology, McGill University, Montreal, Quebec, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Irena","family":"Kukavica-Ibrulj","sequence":"additional","affiliation":[{"name":"Institute for Integrative and Systems Biology, Faculty of Medicine, Universit\u00e9 Laval, Quebec City, Quebec, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brian","family":"Boyle","sequence":"additional","affiliation":[{"name":"Institute for Integrative and Systems Biology, Faculty of Medicine, Universit\u00e9 Laval, Quebec City, Quebec, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Celia M. T.","family":"Greenwood","sequence":"additional","affiliation":[{"name":"Lady Davis Institute for Medical Research, Montreal, Quebec, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lawrence D.","family":"Goodridge","sequence":"additional","affiliation":[{"name":"Food Science Department, University of Guelph, Guelph, Ontario, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rafael","family":"Garduno","sequence":"additional","affiliation":[{"name":"Canadian Food Inspection Agency, Dartmouth Laboratory, Dartmouth, Nova Scotia, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roger C.","family":"Levesque","sequence":"additional","affiliation":[{"name":"Institute for Integrative and Systems Biology, Faculty of Medicine, Universit\u00e9 Laval, Quebec City, Quebec, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Danielle","family":"Malo","sequence":"additional","affiliation":[{"name":"McGill Research Center on Complex Traits, McGill University, Montreal, Quebec, Canada"},{"name":"Department of Human Genetics, McGill University, Montreal, Quebec, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6847-4729","authenticated-orcid":false,"given":"France","family":"Daigle","sequence":"additional","affiliation":[{"name":"D\u00e9partement de Microbiologie, Infectiologie et Immunologie, Universit\u00e9 de Montr\u00e9al, Montreal, Quebec, Canada"},{"name":"Swine and Poultry Infectious Diseases Research Center (CRIPA-FRQNT), Montreal, Quebec, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","unstructured":"WHO. 2018. 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