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Studying transmission parameters such as dose and route of infection is nearly impossible in naturally acquired cases\u2014hence the requirement for a laboratory animal model. Here, we show as a proof of concept that ferrets can be used to study EBOV transmission. We also show that transmission in the absence of direct contact is frequent, as all animals with indirect contact with the infected ferrets had detectable antibodies to the virus, and one succumbed to infection. Our report provides a new small-animal model for studying EBOV transmission that does not require adaptation of the virus, providing insight into virus transmission among humans during epidemics.<\/jats:p>","DOI":"10.1128\/msphere.00309-18","type":"journal-article","created":{"date-parts":[[2018,10,30]],"date-time":"2018-10-30T11:39:32Z","timestamp":1540899572000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":14,"title":["Modeling Ebola Virus Transmission Using Ferrets"],"prefix":"10.1128","volume":"3","author":[{"given":"Marc-Antoine","family":"de La Vega","sequence":"first","affiliation":[{"name":"D\u00e9partement de microbiologie-infectiologie et d\u2019immunologie, Universit\u00e9 Laval, Quebec City, Quebec, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Geoff","family":"Soule","sequence":"additional","affiliation":[{"name":"Special Pathogens Program, National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, Manitoba, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaylie N.","family":"Tran","sequence":"additional","affiliation":[{"name":"Special Pathogens Program, National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, Manitoba, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin","family":"Tierney","sequence":"additional","affiliation":[{"name":"Special Pathogens Program, National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, Manitoba, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shihua","family":"He","sequence":"additional","affiliation":[{"name":"Special Pathogens Program, National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, Manitoba, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gary","family":"Wong","sequence":"additional","affiliation":[{"name":"D\u00e9partement de microbiologie-infectiologie et d\u2019immunologie, Universit\u00e9 Laval, Quebec City, Quebec, Canada"},{"name":"Guangdong Key Laboratory for Diagnosis and Treatment of Emerging Infectious Diseases, Shenzhen Key Laboratory of Pathogen and Immunity, Shenzhen Third People\u2019s Hospital, Shenzhen, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiangguo","family":"Qiu","sequence":"additional","affiliation":[{"name":"Special Pathogens Program, National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, Manitoba, Canada"},{"name":"Department of Medical Microbiology, University of Manitoba, Winnipeg, Manitoba, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0612-2298","authenticated-orcid":false,"given":"Gary P.","family":"Kobinger","sequence":"additional","affiliation":[{"name":"D\u00e9partement de microbiologie-infectiologie et d\u2019immunologie, Universit\u00e9 Laval, Quebec City, Quebec, Canada"},{"name":"Department of Medical Microbiology, University of Manitoba, Winnipeg, Manitoba, Canada"},{"name":"Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1404505"},{"key":"e_1_3_2_3_2","volume-title":"Factors that contributed to undetected spread of the Ebola virus and impeded rapid containment","author":"World Health Organization","year":"2015","unstructured":"World Health Organization. 2015. 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