{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T09:05:37Z","timestamp":1791018337844,"version":"4.1.0"},"reference-count":77,"publisher":"American Society for Microbiology","issue":"5","license":[{"start":{"date-parts":[[2017,9,13]],"date-time":"2017-09-13T00:00:00Z","timestamp":1505260800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2017,10,25]],"date-time":"2017-10-25T00:00:00Z","timestamp":1508889600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"funder":[{"name":"Department of Health's NIHR Biomedical Research Centre"},{"name":"Norwegian Surveillance System for Antibiotic Resistance in Microbes"},{"DOI":"10.13039\/501100005416","name":"Norges Forskningsr\u00e5d","doi-asserted-by":"publisher","award":["241011"],"award-info":[{"award-number":["241011"]}],"id":[{"id":"10.13039\/501100005416","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["mSphere"],"published-print":{"date-parts":[[2017,10,25]]},"abstract":"<jats:p>\n            Quorum sensing regulates bacterial social behaviors by production, secretion, and sensing of pheromones. In this study, we characterized a new quorum-sensing system of the Rgg\/SHP class in\n            <jats:named-content content-type=\"genus-species\">S. pneumoniae<\/jats:named-content>\n            D39. The system was found to directly induce the expression of a single gene cluster comprising the gene for the SHP pheromone and genes with putative functions in capsule synthesis. Capsule size, as measured by dextran exclusion, was increased by SHP exposure in R36A, an unencapsulated derivative of D39. In the encapsulated parent strain, overexpression of the gene cluster increased capsule size, supporting the role of Rgg\/SHP in the synthesis of surface polysaccharides. Further, we found that biofilm formation on epithelial cells was reduced by overexpression of the system and increased in a mutant with an\n            <jats:italic>rgg<\/jats:italic>\n            deletion. Placing surface polysaccharide expression under quorum-sensing regulation may enable\n            <jats:named-content content-type=\"genus-species\">S. pneumoniae<\/jats:named-content>\n            to tune interactions with the host and other bacteria in accordance with environmental and cell density conditions.\n          <\/jats:p>","DOI":"10.1128\/msphere.00324-17","type":"journal-article","created":{"date-parts":[[2017,9,14]],"date-time":"2017-09-14T00:55:37Z","timestamp":1505350537000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":53,"title":["A Quorum-Sensing System That Regulates Streptococcus pneumoniae Biofilm Formation and Surface Polysaccharide Production"],"prefix":"10.1128","volume":"2","author":[{"given":"Roger","family":"Junges","sequence":"first","affiliation":[{"name":"Department of Oral Biology, Faculty of Dentistry, University of Oslo, Oslo, Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriela","family":"Salvadori","sequence":"additional","affiliation":[{"name":"Department of Oral Biology, Faculty of Dentistry, University of Oslo, Oslo, Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sudhanshu","family":"Shekhar","sequence":"additional","affiliation":[{"name":"Department of Oral Biology, Faculty of Dentistry, University of Oslo, Oslo, Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heidi A.","family":"\u00c5mdal","sequence":"additional","affiliation":[{"name":"Department of Oral Biology, Faculty of Dentistry, University of Oslo, Oslo, Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jimstan N.","family":"Periselneris","sequence":"additional","affiliation":[{"name":"Centre for Inflammation and Tissue Repair, Division of Medicine, University College Medical School, Rayne Institute, London, United 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