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In this study, we demonstrated that the\n            <jats:named-content content-type=\"genus-species\">N. gonorrhoeae<\/jats:named-content>\n            adhesin complex protein (Ng-ACP) was conserved and expressed by 50 gonococcal strains and that recombinant proteins induced antibodies in mice that killed the bacteria\n            <jats:italic>in vitro<\/jats:italic>\n            . We determined the structure of Ng-ACP by X-ray crystallography and investigated structural conservation with\n            <jats:named-content content-type=\"genus-species\">Neisseria meningitidis<\/jats:named-content>\n            ACP and MliC\/PliC proteins from other bacteria which act as inhibitors of the human innate defense molecule lysozyme. These findings are important and suggest that Ng-ACP could provide a potential dual target for tackling gonococcal infections.\n          <\/jats:p>","DOI":"10.1128\/msphere.00331-18","type":"journal-article","created":{"date-parts":[[2018,10,9]],"date-time":"2018-10-09T08:39:29Z","timestamp":1539074369000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":30,"title":["Structure of the Recombinant\n            <i>Neisseria gonorrhoeae<\/i>\n            Adhesin Complex Protein (rNg-ACP) and Generation of Murine Antibodies with Bactericidal Activity against Gonococci"],"prefix":"10.1128","volume":"3","author":[{"given":"Hannia Liliana","family":"Almonacid-Mendoza","sequence":"first","affiliation":[{"name":"Neisseria Research Group, Molecular Microbiology, Academic Unit of Clinical and Experimental Sciences, Sir Henry Wellcome Laboratories, University of Southampton Faculty of Medicine, Southampton, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda Victoria","family":"Humbert","sequence":"additional","affiliation":[{"name":"Neisseria Research Group, Molecular Microbiology, Academic Unit of Clinical and Experimental Sciences, Sir Henry Wellcome Laboratories, University of Southampton Faculty of Medicine, Southampton, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aiste","family":"Dijokaite","sequence":"additional","affiliation":[{"name":"Neisseria Research Group, Molecular Microbiology, Academic Unit of Clinical and Experimental Sciences, Sir Henry Wellcome Laboratories, University of Southampton Faculty of Medicine, Southampton, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David W.","family":"Cleary","sequence":"additional","affiliation":[{"name":"Neisseria Research Group, Molecular Microbiology, Academic Unit of Clinical and Experimental Sciences, Sir Henry Wellcome Laboratories, University of Southampton Faculty of Medicine, Southampton, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiwen","family":"Soo","sequence":"additional","affiliation":[{"name":"Neisseria Research Group, Molecular Microbiology, Academic Unit of Clinical and Experimental Sciences, Sir Henry Wellcome Laboratories, University of Southampton Faculty of Medicine, Southampton, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miao-Chiu","family":"Hung","sequence":"additional","affiliation":[{"name":"Neisseria Research Group, Molecular Microbiology, Academic Unit of Clinical and Experimental Sciences, Sir Henry Wellcome Laboratories, University of Southampton Faculty of Medicine, Southampton, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian M.","family":"Orr","sequence":"additional","affiliation":[{"name":"Antibody and Vaccine Group, Cancer Sciences Unit, University of Southampton Faculty of Medicine, Southampton, United Kingdom"},{"name":"Hamburg Centre for Ultrafast Imaging &amp; Institute for Nanostructure and Solid State Physics, University of Hamburg, Hamburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Moritz M.","family":"Machelett","sequence":"additional","affiliation":[{"name":"Biological Sciences, Institute for Life Sciences, University of Southampton, Southampton, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ivo","family":"Tews","sequence":"additional","affiliation":[{"name":"Biological Sciences, Institute for Life Sciences, University of Southampton, Southampton, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9663-4731","authenticated-orcid":false,"given":"Myron","family":"Christodoulides","sequence":"additional","affiliation":[{"name":"Neisseria Research Group, Molecular Microbiology, Academic Unit of Clinical and Experimental Sciences, Sir Henry Wellcome Laboratories, University of Southampton Faculty of Medicine, Southampton, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.idc.2013.08.004"},{"key":"e_1_3_2_3_2","first-page":"931","article-title":"Diagnosis and management of gonococcal infections","volume":"86","author":"Mayor MT","year":"2012","unstructured":"Mayor MT, Roett MA, Uduhiri KA. 2012. 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