{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T03:41:00Z","timestamp":1790912460876,"version":"4.1.0"},"reference-count":33,"publisher":"American Society for Microbiology","issue":"5","license":[{"start":{"date-parts":[[2019,9,4]],"date-time":"2019-09-04T00:00:00Z","timestamp":1567555200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2019,10,30]],"date-time":"2019-10-30T00:00:00Z","timestamp":1572393600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"funder":[{"DOI":"10.13039\/100000002","name":"HHS | National Institutes of Health","doi-asserted-by":"publisher","award":["CDMRP award PR171482"],"award-info":[{"award-number":["CDMRP award PR171482"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["mSphere"],"published-print":{"date-parts":[[2019,10,30]]},"abstract":"<jats:p>\n            In the last decade,\n            <jats:named-content content-type=\"genus-species\">Candida auris<\/jats:named-content>\n            has emerged globally as a multidrug\u2010resistant fungal pathogen. Although\n            <jats:named-content content-type=\"genus-species\">C. auris<\/jats:named-content>\n            was initially isolated from the external ear canal, it can cause outbreaks of invasive infections with very high mortality and comorbidities. Recent reports highlight the ongoing challenges due to organism misidentification, high rates of multifungal drug resistance, and unacceptably high patient mortality. The assessment of\n            <jats:named-content content-type=\"genus-species\">C. auris<\/jats:named-content>\n            virulence in a specific genetic deficiency mouse model of invasive\n            <jats:named-content content-type=\"genus-species\">C. auris<\/jats:named-content>\n            infection in this study contributes to the little knowledge of host defense to\n            <jats:named-content content-type=\"genus-species\">C. auris<\/jats:named-content>\n            infection, which holds promise as a model for investigating the pathogenesis of\n            <jats:named-content content-type=\"genus-species\">C. auris<\/jats:named-content>\n            invasive infection, exploring the immune responses elicited by the fungus, evaluating the possible induction of immunity to the infection, and targeting candidates for an antifungal vaccine.\n          <\/jats:p>","DOI":"10.1128\/msphere.00339-19","type":"journal-article","created":{"date-parts":[[2019,9,4]],"date-time":"2019-09-04T13:59:16Z","timestamp":1567605556000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":62,"title":["Experimental Mouse Models of Disseminated Candida auris Infection"],"prefix":"10.1128","volume":"4","author":[{"given":"Hong","family":"Xin","sequence":"first","affiliation":[{"name":"LSU Health Sciences Center New Orleans, New Orleans, Louisiana, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Farhan","family":"Mohiuddin","sequence":"additional","affiliation":[{"name":"Loyola University New Orleans, New Orleans, Louisiana, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jensen","family":"Tran","sequence":"additional","affiliation":[{"name":"Loyola University New Orleans, New Orleans, Louisiana, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abby","family":"Adams","sequence":"additional","affiliation":[{"name":"LSU Health Sciences Center New Orleans, New Orleans, Louisiana, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karen","family":"Eberle","sequence":"additional","affiliation":[{"name":"LSU Health Sciences Center New Orleans, New Orleans, Louisiana, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/cix460"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/mbo3.578"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1128\/mBio.01403-18"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.3390\/jof4010021"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0923-2494(98)80752-9"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2018.03081"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1111\/myc.12754"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.3201\/eid2302.161486"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41426-018-0095-0"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1128\/mSphere.00189-16"},{"key":"e_1_3_2_12_2","first-page":"1","article-title":"When and how to treat serious candidial infections: concepts and controversies","volume":"15","author":"Filler SG","year":"1995","unstructured":"Filler SG, Edwards JE. 1995. 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