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During infection,\n            <jats:italic>Aspergillus<\/jats:italic>\n            grows, forming hyphae that colonize the lung tissue and invade and spread over the mammal host, resulting in high mortality rates. The knowledge of the mechanisms responsible for regulation of fungal growth and virulence comprises an important point to better understand fungal physiology and host-pathogen interactions. Msb2 is a mucin that acts as a sensor and an upstream regulator of the MAPK pathway responsible for fungal development in\n            <jats:named-content content-type=\"genus-species\">Candida albicans<\/jats:named-content>\n            and\n            <jats:named-content content-type=\"genus-species\">Aspergillus nidulans<\/jats:named-content>\n            . Here, we show the role of the signaling mucin MsbA in the pathogen\n            <jats:named-content content-type=\"genus-species\">A. fumigatus<\/jats:named-content>\n            , as a core sensor for cell wall morphogenesis, fungal growth, and virulence. Moreover, we show that cell wall composition, controlled by MsbA, is detrimental for fungal recognition and clearance by immune cells. Our findings are important for the understanding of how fungal sensors modulate cell physiology.\n          <\/jats:p>","DOI":"10.1128\/msphere.00350-19","type":"journal-article","created":{"date-parts":[[2019,6,18]],"date-time":"2019-06-18T11:34:51Z","timestamp":1560857691000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":16,"title":["The\n            <i>Aspergillus fumigatus<\/i>\n            Mucin MsbA Regulates the Cell Wall Integrity Pathway and Controls Recognition of the Fungus by the Immune System"],"prefix":"10.1128","volume":"4","author":[{"given":"Isabella Lu\u00edsa da Silva","family":"Gurgel","sequence":"first","affiliation":[{"name":"Centro de Pesquisa e Desenvolvimento de F\u00e1rmacos, Instituto de Ci\u00eancias Biol\u00f3gicas, Departamento de Gen\u00e9tica, Ecologia e Evolu\u00e7\u00e3o, Universidade Federal de Minas Gerais, Belo Horizonte, 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Marques","family":"Souza","sequence":"additional","affiliation":[{"name":"Centro de Pesquisa e Desenvolvimento de F\u00e1rmacos, Instituto de Ci\u00eancias Biol\u00f3gicas, Departamento de Gen\u00e9tica, Ecologia e Evolu\u00e7\u00e3o, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marina Campos","family":"Rocha","sequence":"additional","affiliation":[{"name":"Departamento de Gen\u00e9tica e Evolu\u00e7\u00e3o, Centro de Ci\u00eancias Biol\u00f3gicas e da Sa\u00fade, Universidade Federal de S\u00e3o Carlos, S\u00e3o Carlos, S\u00e3o Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marina Faria","family":"Fernandes","sequence":"additional","affiliation":[{"name":"Centro de Pesquisa e Desenvolvimento de F\u00e1rmacos, Instituto de Ci\u00eancias Biol\u00f3gicas, Departamento de Gen\u00e9tica, Ecologia e Evolu\u00e7\u00e3o, Universidade Federal de Minas Gerais, Belo Horizonte, 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A comparative study of lysosomal enzyme activity in monocytes and Kupffer cells isolated simultaneously in a rat model of liver injury. 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