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Developmental regulation of mitochondrial activities is an essential part of these processes. We have shown previously that mitochondrial inner membrane protein translocase 50 in\n                    <jats:named-content content-type=\"genus-species\">T. brucei<\/jats:named-content>\n                    (TbTim50) possesses a dually specific phosphatase activity and plays a role in the cellular stress response pathway. Using proteomics analysis, here we have elucidated a novel connection between TbTim50 and a protein phosphatase of the same family, PIP39, which is also a differentiation-related protein localized in glycosomes. We found that these two protein phosphatases cross talk via the AMPK pathway and modulate cellular metabolic activities under stress. Together, our results indicate the importance of a TbTim50 and PIP39 cascade for communication between mitochondria and other cellular parts in regulation of cell homeostasis in\n                    <jats:named-content content-type=\"genus-species\">T. brucei<\/jats:named-content>\n                    .\n                  <\/jats:p>","DOI":"10.1128\/msphere.00353-19","type":"journal-article","created":{"date-parts":[[2019,8,6]],"date-time":"2019-08-06T09:23:24Z","timestamp":1565083404000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":4,"title":["The Cross Talk between TbTim50 and PIP39, Two Aspartate-Based Protein Phosphatases, Maintains Cellular Homeostasis in Trypanosoma brucei"],"prefix":"10.1128","volume":"4","author":[{"given":"Anuj","family":"Tripathi","sequence":"first","affiliation":[{"name":"Department of Microbiology, Immunology, and Physiology, Meharry Medical College, Nashville, Tennessee, 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