{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T14:49:19Z","timestamp":1792594159736,"version":"4.5.0"},"reference-count":40,"publisher":"American Society for Microbiology","issue":"1","license":[{"start":{"date-parts":[[2017,1,11]],"date-time":"2017-01-11T00:00:00Z","timestamp":1484092800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2017,2,22]],"date-time":"2017-02-22T00:00:00Z","timestamp":1487721600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["mSphere"],"published-print":{"date-parts":[[2017,2,22]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Cryptococcosis is a potentially lethal disease of humans\/animals caused by\n                    <jats:named-content content-type=\"genus-species\">Cryptococcus neoformans<\/jats:named-content>\n                    and\n                    <jats:named-content content-type=\"genus-species\">Cryptococcus gattii<\/jats:named-content>\n                    . Distinction between the two species is based on phenotypic and genotypic characteristics. Recently, it was proposed that\n                    <jats:named-content content-type=\"genus-species\">C. neoformans<\/jats:named-content>\n                    be divided into two species and\n                    <jats:named-content content-type=\"genus-species\">C. gattii<\/jats:named-content>\n                    into five species based on a phylogenetic analysis of 115 isolates. While this proposal adds to the knowledge about the genetic diversity and population structure of cryptococcosis agents, the published genotypes of 2,606 strains have already revealed more genetic diversity than is encompassed by seven species. Naming every clade as a separate species at this juncture will lead to continuing nomenclatural instability. In the absence of biological differences between clades and no consensus about how DNA sequence alone can delineate a species, we recommend using \u201c\n                    <jats:named-content content-type=\"genus-species\">Cryptococcus neoformans<\/jats:named-content>\n                    species complex\u201d and \u201c\n                    <jats:named-content content-type=\"genus-species\">C. gattii<\/jats:named-content>\n                    species complex\u201d as a practical intermediate step, rather than creating more species. This strategy recognizes genetic diversity without creating confusion.\n                  <\/jats:p>","DOI":"10.1128\/msphere.00357-16","type":"journal-article","created":{"date-parts":[[2017,1,11]],"date-time":"2017-01-11T21:10:53Z","timestamp":1484169053000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":292,"title":["The Case for Adopting the \u201cSpecies Complex\u201d Nomenclature for the Etiologic Agents of Cryptococcosis"],"prefix":"10.1128","volume":"2","author":[{"given":"Kyung J.","family":"Kwon-Chung","sequence":"first","affiliation":[{"name":"Laboratory of Clinical Infectious Diseases, NIAID, NIH, Bethesda, Maryland, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John E.","family":"Bennett","sequence":"additional","affiliation":[{"name":"Laboratory of Clinical Infectious Diseases, NIAID, NIH, Bethesda, Maryland, 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