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Protein-protein interactions (PPIs) can be applied as very specific drug targets. However, because of the aberrant codon usage of\n                    <jats:named-content content-type=\"genus-species\">C.\u00a0albicans<\/jats:named-content>\n                    , the traditional yeast two-hybrid system in\n                    <jats:named-content content-type=\"genus-species\">Saccharomyces cerevisiae<\/jats:named-content>\n                    is difficult to use, and only a limited number of PPIs have been described in\n                    <jats:named-content content-type=\"genus-species\">C.\u00a0albicans<\/jats:named-content>\n                    . To overcome this, a\n                    <jats:named-content content-type=\"genus-species\">C.\u00a0albicans<\/jats:named-content>\n                    two-hybrid (C2H) system was developed in 2010. The current work describes, for the first time, the application of the C2H system in a high-throughput setup. We hereby show the usefulness of the C2H system to investigate and detect PPIs in\n                    <jats:named-content content-type=\"genus-species\">C.\u00a0albicans<\/jats:named-content>\n                    , making it possible to further elucidate protein networks in\n                    <jats:named-content content-type=\"genus-species\">C.\u00a0albicans<\/jats:named-content>\n                    , which has the potential to lead to the development of novel antifungals which specifically disrupt PPIs important for virulence.\n                  <\/jats:p>","DOI":"10.1128\/msphere.00391-18","type":"journal-article","created":{"date-parts":[[2018,8,28]],"date-time":"2018-08-28T05:48:55Z","timestamp":1535435335000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":13,"title":["A High-Throughput\n                    <i>Candida albicans<\/i>\n                    Two-Hybrid 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