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Meningococcal species are subdivided into serogroups on the basis of different sugar capsules. Vaccines that target serogroup A, C, Y, and W capsules are safe and highly effective. New serogroup B (MenB) vaccines target a bacterial protein that can bind to a blood protein called complement factor H (FH). While serogroup B vaccines appear to be safe and effective, there is a theoretical risk that immunization with a bacterial protein that binds host FH might elicit anti-FH autoantibodies. Autoantibodies to FH have been detected in healthy persons but in rare cases can cause certain autoimmune diseases. We found small and\/or transient increases in serum antibody to FH after MenB immunization. While no serious adverse events were reported in the subjects with elevated anti-FH titers, since onset of autoimmune disease is a rare event and may occur months or years after vaccination, additional, larger studies are warranted.<\/jats:p>","DOI":"10.1128\/msphere.00393-19","type":"journal-article","created":{"date-parts":[[2019,7,2]],"date-time":"2019-07-02T10:32:16Z","timestamp":1562063536000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":10,"title":["Anti-Factor H Antibody Reactivity in Young Adults Vaccinated with a Meningococcal Serogroup B Vaccine Containing Factor H Binding Protein"],"prefix":"10.1128","volume":"4","author":[{"given":"Kelsey","family":"Sharkey","sequence":"first","affiliation":[{"name":"Center for Immunobiology and Vaccine Development, University of California San Francisco Benioff Children\u2019s Hospital Oakland, Oakland, California, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5734-083X","authenticated-orcid":false,"given":"Peter T.","family":"Beernink","sequence":"additional","affiliation":[{"name":"Center for Immunobiology and Vaccine Development, University of California San Francisco Benioff Children\u2019s Hospital Oakland, Oakland, California, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joanne M.","family":"Langley","sequence":"additional","affiliation":[{"name":"IWK Health Centre and the Nova Scotia Health Authority, Canadian Center for Vaccinology at Dalhousie University, Halifax, Nova Scotia, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Soren","family":"Gantt","sequence":"additional","affiliation":[{"name":"BC Children\u2019s Hospital Research Institute, Vancouver, British Columbia, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Caroline","family":"Quach","sequence":"additional","affiliation":[{"name":"McGill University Health Centre Research Institute and CHU Sainte Justine, Montreal, Quebec, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christina","family":"Dold","sequence":"additional","affiliation":[{"name":"University of Oxford, Oxford, United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qin","family":"Liu","sequence":"additional","affiliation":[{"name":"Wistar Institute, Philadelphia, Pennsylvania, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manuel","family":"Galvan","sequence":"additional","affiliation":[{"name":"National Jewish Health Complement Laboratory, Denver, Colorado, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dan M.","family":"Granoff","sequence":"additional","affiliation":[{"name":"Center for Immunobiology and Vaccine Development, University of California San Francisco Benioff Children\u2019s Hospital Oakland, Oakland, California, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/s0140-6736(83)90340-9"},{"key":"e_1_3_2_3_2","first-page":"644","volume-title":"Vaccines","author":"Granoff DM","year":"2018","unstructured":"Granoff DM, Pollard AJ, Harrison LH. 2018. 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