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The development of an improved\n            <jats:italic>Shigella<\/jats:italic>\n            CHIM for both\n            <jats:named-content content-type=\"genus-species\">Shigella sonnei<\/jats:named-content>\n            and\n            <jats:named-content content-type=\"genus-species\">Shigella flexneri<\/jats:named-content>\n            is consistent with international efforts, supported by international donors and the World Health Organization, focused on standardizing\n            <jats:italic>Shigella<\/jats:italic>\n            CHIMs and using them to accelerate\n            <jats:italic>Shigella<\/jats:italic>\n            vaccine development. The use of lyophilized\n            <jats:italic>Shigella<\/jats:italic>\n            challenge strains rather than plate-grown inoculum preparations is considered an important step forward in the standardization process. Furthermore, the results of studies such as this justify the development of lyophilized preparations for additional epidemiologically important\n            <jats:named-content content-type=\"genus-species\">S. flexneri<\/jats:named-content>\n            serotypes, including\n            <jats:named-content content-type=\"genus-species\">S. flexneri<\/jats:named-content>\n            3a and\n            <jats:named-content content-type=\"genus-species\">S. flexneri<\/jats:named-content>\n            6.\n          <\/jats:p>","DOI":"10.1128\/msphere.00416-20","type":"journal-article","created":{"date-parts":[[2020,9,22]],"date-time":"2020-09-22T13:55:19Z","timestamp":1600782919000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":20,"title":["Establishment of a Controlled Human Infection Model with a Lyophilized Strain of Shigella sonnei 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