{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T17:08:25Z","timestamp":1790960905176,"version":"4.1.0"},"reference-count":39,"publisher":"American Society for Microbiology","issue":"1","license":[{"start":{"date-parts":[[2018,1,31]],"date-time":"2018-01-31T00:00:00Z","timestamp":1517356800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2018,2,28]],"date-time":"2018-02-28T00:00:00Z","timestamp":1519776000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"funder":[{"DOI":"10.13039\/100000002","name":"HHS | National Institutes of Health","doi-asserted-by":"publisher","award":["AI104067"],"award-info":[{"award-number":["AI104067"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009790","name":"SUNY | University at Albany","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009790","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["mSphere"],"published-print":{"date-parts":[[2018,2,28]]},"abstract":"<jats:p>\n            Genital infection with\n            <jats:named-content content-type=\"genus-species\">Neisseria gonorrhoeae<\/jats:named-content>\n            (gonorrhea) is a significant cause of reproductive tract morbidity in women, leading to pelvic inflammatory disease, tubal factor infertility, and increased risk for ectopic pregnancy. WHO estimates that 78 million new infections occur annually worldwide. In the United States, &gt;350,000 cases are reported annually, but the true incidence is probably &gt;800,000 cases\/year. Increasing resistance to currently available antibiotics raises concern that gonorrhea might become untreatable. Infection does not induce a state of immune protection against reinfection. Previous studies have shown that\n            <jats:named-content content-type=\"genus-species\">N. gonorrhoeae<\/jats:named-content>\n            suppresses the development of adaptive immune responses by mechanisms dependent on the regulatory cytokines TGF-\u03b2 and IL-10. This study shows that intravaginal treatment of gonococcal infection in female mice with microencapsulated IL-12 induces persisting anamnestic immunity against reinfection with\n            <jats:named-content content-type=\"genus-species\">N. gonorrhoeae<\/jats:named-content>\n            , even of antigenically diverse strains, dependent on T-cell production of IFN-\u03b3 and B-cell production of antibodies.\n          <\/jats:p>","DOI":"10.1128\/msphere.00421-17","type":"journal-article","created":{"date-parts":[[2018,1,30]],"date-time":"2018-01-30T12:31:56Z","timestamp":1517315516000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":35,"title":["Intravaginal Administration of Interleukin 12 during Genital Gonococcal Infection in Mice Induces Immunity to Heterologous Strains of Neisseria gonorrhoeae"],"prefix":"10.1128","volume":"3","author":[{"given":"Yingru","family":"Liu","sequence":"first","affiliation":[{"name":"TherapyX, Inc., Buffalo, New York, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julianny","family":"Perez","sequence":"additional","affiliation":[{"name":"TherapyX, Inc., Buffalo, New York, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura A.","family":"Hammer","sequence":"additional","affiliation":[{"name":"TherapyX, Inc., Buffalo, New York, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heather C.","family":"Gallagher","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences, University at Albany, Albany, New York, USA"},{"name":"Division of Infectious Diseases, Wadsworth Center, New York State Department of Health, Albany, New York, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Magdia","family":"De Jesus","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences, University at Albany, Albany, New York, USA"},{"name":"Division of Infectious Diseases, Wadsworth Center, New York State Department of Health, Albany, New York, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nejat K.","family":"Egilmez","sequence":"additional","affiliation":[{"name":"TherapyX, Inc., Buffalo, New York, USA"},{"name":"Department of Microbiology and Immunology, University of Louisville, Louisville, Kentucky, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael W.","family":"Russell","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, University at Buffalo, Buffalo, New York, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-369408-9.00049-4"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2011.00124"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2013.08.067"},{"key":"e_1_3_2_5_2","first-page":"123","volume-title":"Neisseria: molecular mechanisms of pathogenesis","author":"Lewis LA","year":"2010","unstructured":"Lewis LA, Burrowes E, Rice PA, Ram S. 2010. 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