{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,27]],"date-time":"2026-05-27T18:39:19Z","timestamp":1779907159606,"version":"3.53.1"},"reference-count":22,"publisher":"American Society for Microbiology","issue":"3","license":[{"start":{"date-parts":[[2021,6,30]],"date-time":"2021-06-30T00:00:00Z","timestamp":1625011200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2021,6,30]],"date-time":"2021-06-30T00:00:00Z","timestamp":1625011200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"funder":[{"DOI":"10.13039\/100000072","name":"HHS | NIH | National Institute of Dental and Craniofacial Research","doi-asserted-by":"publisher","award":["R01 DE024607"],"award-info":[{"award-number":["R01 DE024607"]}],"id":[{"id":"10.13039\/100000072","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["mSphere"],"published-print":{"date-parts":[[2021,6,30]]},"abstract":"<jats:p>\n            The anaerobic bacterium\n            <jats:named-content content-type=\"genus-species\">Porphyromonas gingivalis<\/jats:named-content>\n            is not only the major etiologic agent for chronic periodontitis, but also prevalent in some common noncommunicable diseases such as cardiovascular disease, Alzheimer's disease, and rheumatoid arthritis. We present genetic, biochemical, and biological results to demonstrate that the PorX\/PorY two-component system and sigma factor \u03c3\n            <jats:sup>P<\/jats:sup>\n            build a specific regulatory network to coordinately control transcription of the genes encoding the type IX secretion system, and perhaps also other virulence factors.\n          <\/jats:p>","DOI":"10.1128\/msphere.00428-21","type":"journal-article","created":{"date-parts":[[2021,6,11]],"date-time":"2021-06-11T01:53:35Z","timestamp":1623376415000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":13,"title":["A PorX\/PorY and \u03c3\n            <sup>P<\/sup>\n            Feedforward Regulatory Loop Controls Gene Expression Essential for Porphyromonas gingivalis Virulence"],"prefix":"10.1128","volume":"6","author":[{"given":"Chizhou","family":"Jiang","sequence":"first","affiliation":[{"name":"School of Life Sciences, Arizona State 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