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To inform vaccine development for group A\n                    <jats:italic>Streptococcus<\/jats:italic>\n                    (GAS), we report on the epidemiology of the M protein\n                    <jats:italic>emm<\/jats:italic>\n                    clusters from GAS infections in Africa, where GAS-related illnesses and their sequelae, including rheumatic fever and rheumatic heart disease, are of a high burden. This first report of\n                    <jats:italic>emm<\/jats:italic>\n                    clusters across the continent indicates a high probably of coverage by the M protein-based vaccine currently undergoing testing were an\n                    <jats:italic>emm<\/jats:italic>\n                    -cluster based approach to be used.\n                  <\/jats:p>","DOI":"10.1128\/msphere.00429-20","type":"journal-article","created":{"date-parts":[[2020,7,14]],"date-time":"2020-07-14T10:30:02Z","timestamp":1594722602000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":18,"title":["Systematic Review and Meta-analysis of the Prevalence of Group A Streptococcal\n                    <i>emm<\/i>\n                    Clusters in Africa To Inform Vaccine Development"],"prefix":"10.1128","volume":"5","author":[{"given":"Taariq","family":"Salie","sequence":"first","affiliation":[{"name":"AFROStrep Research Group, Department of Medicine, Faculty of Health Sciences, University of Cape Town &amp; Groote Schuur Hospital, Cape Town, South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kelin","family":"Engel","sequence":"additional","affiliation":[{"name":"AFROStrep Research Group, Department of Medicine, Faculty of Health Sciences, University of Cape Town &amp; Groote Schuur Hospital, Cape Town, South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annesinah","family":"Moloi","sequence":"additional","affiliation":[{"name":"AFROStrep Research Group, Department of Medicine, Faculty of Health Sciences, University of Cape Town &amp; Groote Schuur Hospital, Cape Town, South Africa"},{"name":"Health Systems Research Unit, South African Medical Research Council, Cape Town, South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Babu","family":"Muhamed","sequence":"additional","affiliation":[{"name":"AFROStrep Research Group, Department of Medicine, Faculty of Health Sciences, University of Cape Town &amp; Groote Schuur Hospital, Cape Town, South Africa"},{"name":"Children's National Health System, Division of Cardiology, Washington, DC, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James B.","family":"Dale","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, Department of Medicine, University of Tennessee Health Science Center, Memphis, Tennessee, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1334-8829","authenticated-orcid":false,"given":"Mark E.","family":"Engel","sequence":"additional","affiliation":[{"name":"AFROStrep Research Group, Department of Medicine, Faculty of Health Sciences, University of Cape Town &amp; Groote Schuur Hospital, Cape Town, South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(05)70267-X"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000441-199601000-00008"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1097\/QCO.0b013e328339257c"},{"key":"e_1_3_2_5_2","first-page":"475","article-title":"Update on acute rheumatic fever: it still exists in remote communities","volume":"55","author":"Madden S","year":"2009","unstructured":"Madden S, Kelly L. 2009. 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