{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T01:19:20Z","timestamp":1788311960618,"version":"build-2803163510"},"reference-count":24,"publisher":"American Society for Microbiology","issue":"1","license":[{"start":{"date-parts":[[2018,1,10]],"date-time":"2018-01-10T00:00:00Z","timestamp":1515542400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2018,2,28]],"date-time":"2018-02-28T00:00:00Z","timestamp":1519776000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["mSphere"],"published-print":{"date-parts":[[2018,2,28]]},"abstract":"<jats:p>\n            Approximately 100 cases of POWV disease were reported in the United States over the past 10 years. Most cases have occurred in the Northeast (52) and Great Lakes (45) regions (\n            <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"https:\/\/www.cdc.gov\/powassan\/statistics.html\">https:\/\/www.cdc.gov\/powassan\/statistics.html<\/jats:ext-link>\n            ). The prevalence of POWV in ticks and mammals is increasing, and POWV poses an increasing threat in a greater geographical range. In areas of the Northeast and Midwest where Lyme disease is endemic, POWV testing is recommended for patients with a recent tick bite, patients with Lyme disease who have been treated with antibiotics, or patients with a tick exposure who have tested negative for Lyme disease or other tick-borne illnesses and have persistent symptoms consistent with posttreatment Lyme disease. Testing could also benefit patients with tick exposure and unexplained neurologic symptoms and chronic fatigue syndrome (CFS) patients with known tick exposure. Until now, diagnostic testing for Powassan virus has not been commercially available and has been limited to patients presenting with severe, neurologic complications. The lack of routine testing for Powassan virus in patients with suspected tick-borne disease means that little information is available regarding the overall prevalence of the virus and the full spectrum of clinical symptoms associated with infection. As\n            <jats:named-content content-type=\"genus-species\">Ixodes scapularis<\/jats:named-content>\n            is the tick vector for Powassan virus and multiple other tick-borne pathogens, including the Lyme disease bacterium,\n            <jats:named-content content-type=\"genus-species\">Borrelia burgdorferi<\/jats:named-content>\n            , the clinical presentations and long-term outcomes of Powassan virus infection and concurrent infection with other tick-borne disease pathogens remain unknown.\n          <\/jats:p>","DOI":"10.1128\/msphere.00467-17","type":"journal-article","created":{"date-parts":[[2018,1,8]],"date-time":"2018-01-08T10:39:07Z","timestamp":1515407947000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":22,"title":["Development and Validation of a Serologic Test Panel for Detection of Powassan Virus Infection in U.S. Patients Residing in Regions Where Lyme Disease Is Endemic"],"prefix":"10.1128","volume":"3","author":[{"given":"Angela M.","family":"Thomm","sequence":"first","affiliation":[{"name":"Coppe Laboratories, Waukesha, Wisconsin, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna M.","family":"Schotthoefer","sequence":"additional","affiliation":[{"name":"Marshfield Clinic Research Foundation, Marshfield, Wisconsin, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"II","given":"Alan P.","family":"Dupuis","sequence":"additional","affiliation":[{"name":"Wadsworth Center, New York State Department of Health, Slingerlands, New York, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura D.","family":"Kramer","sequence":"additional","affiliation":[{"name":"Wadsworth Center, New York State Department of Health, Slingerlands, New York, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Holly M.","family":"Frost","sequence":"additional","affiliation":[{"name":"Marshfield Clinic, Marshfield, Wisconsin, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas R.","family":"Fritsche","sequence":"additional","affiliation":[{"name":"Marshfield Clinic, Marshfield, Wisconsin, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yvette A.","family":"Harrington","sequence":"additional","affiliation":[{"name":"Coppe Laboratories, Waukesha, Wisconsin, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Konstance K.","family":"Knox","sequence":"additional","affiliation":[{"name":"Coppe Laboratories, Waukesha, Wisconsin, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sue C.","family":"Kehl","sequence":"additional","affiliation":[{"name":"Medical College of Wisconsin, Milwaukee, Wisconsin, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.4172\/2157-2526.S1-003"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1099\/0022-1317-82-7-1657"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1086\/508667"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-ento-112408-085446"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1093\/jme\/tjv237"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.12-0586"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1089\/vbz.2016.2082"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.3201\/eid0504.990423"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0065-3527(03)61008-0"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.3201\/eid1909.121846"},{"key":"e_1_3_2_12_2","volume-title":"Clinical and lab evaluations","author":"Centers for Disease Control and Prevention","year":"2015","unstructured":"Centers for Disease Control and Prevention. 9 February 2015. Powassan virus. Clinical and lab evaluations. Centers for Disease Control and Prevention, Atlanta, GA. http:\/\/www.cdc.gov\/powassan\/clinicallabeval.html."},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1286-4579(02)01647-7"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jviromet.2006.09.009"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.2807\/1560-7917.ES.2015.20.41.30042"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12879-015-0877-0"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1089\/vim.2008.0007"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1128\/CVI.00201-10"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.42.10.4641-4648.2004"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1128\/CVI.00078-07"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1086\/591467"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.3201\/eid2308.161971"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1186\/1756-3305-6-185"},{"key":"e_1_3_2_24_2","volume-title":"Data and statistics","author":"Centers for Disease Control and Prevention","year":"2017","unstructured":"Centers for Disease Control and Prevention. 13 November 2017. Lyme disease. Data and statistics. Centers for Disease Control and Prevention, Atlanta, GA. http:\/\/www.cdc.gov\/lyme\/stats\/index.html."},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.72.1.73-83.1998"}],"container-title":["mSphere"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/mSphere.00467-17","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/mSphere.00467-17","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,8]],"date-time":"2022-03-08T04:09:08Z","timestamp":1646712548000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/mSphere.00467-17"}},"subtitle":[],"editor":[{"given":"Ana","family":"Fernandez-Sesma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2018,2,28]]},"references-count":24,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2018,2,28]]}},"alternative-id":["10.1128\/mSphere.00467-17"],"URL":"https:\/\/doi.org\/10.1128\/msphere.00467-17","relation":{},"ISSN":["2379-5042"],"issn-type":[{"value":"2379-5042","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,2,28]]},"assertion":[{"value":"2017-10-04","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2017-12-11","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-01-10","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e00467-17"}}