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Current treatments are unable to cure<jats:named-content content-type=\"genus-species\">T. gondii<\/jats:named-content>infection, leaving infected individuals with slow-growing tissue cysts for the remainder of their lives. Previous work has shown that expression of the parasite protein mitochondrial association factor 1 (MAF1b) is responsible for the association of<jats:named-content content-type=\"genus-species\">T. gondii<\/jats:named-content>parasites with host mitochondria and provides a selective advantage during acute infection. Here we examine the impact of MAF1b expression during chronic<jats:named-content content-type=\"genus-species\">T. gondii<\/jats:named-content>infection. We find that mice infected with MAF1b-expressing parasites have higher cyst burden and cytokine levels than their wild-type counterparts. A better understanding of the genes involved in establishing and maintaining chronic infection will aid in discovering effective therapeutics for chronically infected individuals.<\/jats:p>","DOI":"10.1128\/msphere.00471-18","type":"journal-article","created":{"date-parts":[[2018,10,23]],"date-time":"2018-10-23T14:37:58Z","timestamp":1540305478000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":13,"title":["Impact of Engineered Expression of Mitochondrial Association Factor 1b on<i>Toxoplasma gondii<\/i>Infection and the Host Response in a Mouse Model"],"prefix":"10.1128","volume":"3","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2246-8697","authenticated-orcid":false,"given":"Elizabeth D.","family":"English","sequence":"first","affiliation":[{"name":"Department of Biological Sciences, Kenneth P. 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