{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T13:51:04Z","timestamp":1762005064572,"version":"3.41.2"},"reference-count":50,"publisher":"American Society for Microbiology","issue":"6","license":[{"start":{"date-parts":[[2018,11,28]],"date-time":"2018-11-28T00:00:00Z","timestamp":1543363200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2018,12,26]],"date-time":"2018-12-26T00:00:00Z","timestamp":1545782400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"funder":[{"name":"NIH\/NIAID","award":["U19 AI109776-01"],"award-info":[{"award-number":["U19 AI109776-01"]}]},{"name":"NIH\/NIAID","award":["U19 AI110820"],"award-info":[{"award-number":["U19 AI110820"]}]},{"DOI":"10.13039\/100000104","name":"NASA","doi-asserted-by":"crossref","award":["NNX13AN80G"],"award-info":[{"award-number":["NNX13AN80G"]}],"id":[{"id":"10.13039\/100000104","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["mSphere"],"published-print":{"date-parts":[[2018,12,26]]},"abstract":"<jats:p>\n            We developed a live attenuated\n            <jats:named-content content-type=\"genus-species\">Salmonella enterica<\/jats:named-content>\n            serovar Paratyphi B vaccine that conferred protection in mice against challenge with\n            <jats:italic>S<\/jats:italic>\n            . Paratyphi B\n            <jats:italic>sensu stricto<\/jats:italic>\n            and\n            <jats:italic>S<\/jats:italic>\n            . Paratyphi B Java, which are the causes of enteric fever and gastroenteritis, respectively. Currently, the incidence of invasive\n            <jats:italic>S.<\/jats:italic>\n            Paratyphi B\n            <jats:italic>sensu stricto<\/jats:italic>\n            infections is low; however, the development of new conjugate vaccines against other enteric fever serovars could lead to the emergence of\n            <jats:italic>S.<\/jats:italic>\n            Paratyphi B to fill the niche left by these other pathogens. As such, an effective\n            <jats:italic>S.<\/jats:italic>\n            Paratyphi B vaccine would be a useful tool in the armamentarium against\n            <jats:named-content content-type=\"genus-species\">Salmonella<\/jats:named-content>\n            infections. Comparative genomics confirmed the serovar-specific groupings of these isolates and revealed that there are a limited number of genetic differences between the\n            <jats:italic>sensu stricto<\/jats:italic>\n            and Java strains, which are mostly hypothetical and phage-encoded proteins. The observed level of genomic similarity likely explains why we observe some cross-protection.\n          <\/jats:p>","DOI":"10.1128\/msphere.00474-18","type":"journal-article","created":{"date-parts":[[2018,11,27]],"date-time":"2018-11-27T11:37:48Z","timestamp":1543318668000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":12,"title":["Improving Our Understanding of\n            <i>Salmonella enterica<\/i>\n            Serovar Paratyphi B through the Engineering and Testing of a Live Attenuated Vaccine Strain"],"prefix":"10.1128","volume":"3","author":[{"given":"Ellen E.","family":"Higginson","sequence":"first","affiliation":[{"name":"Center for Vaccine Development and Global Health, University of Maryland School of Medicine, Baltimore, Maryland, USA"},{"name":"Department of Medicine, University of Maryland School of Medicine, Baltimore, Maryland, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Girish","family":"Ramachandran","sequence":"additional","affiliation":[{"name":"Center for Vaccine Development and Global Health, University of Maryland School of Medicine, Baltimore, Maryland, USA"},{"name":"Department of Medicine, University of Maryland School of Medicine, Baltimore, Maryland, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tracy H.","family":"Hazen","sequence":"additional","affiliation":[{"name":"Institute for Genome Sciences, Department of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, Maryland, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dane A.","family":"Kania","sequence":"additional","affiliation":[{"name":"Institute for Genome Sciences, Department of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, Maryland, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7337-7154","authenticated-orcid":false,"given":"David A.","family":"Rasko","sequence":"additional","affiliation":[{"name":"Institute for Genome Sciences, Department of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, Maryland, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcela F.","family":"Pasetti","sequence":"additional","affiliation":[{"name":"Center for Vaccine Development and Global Health, University of Maryland School of Medicine, Baltimore, Maryland, USA"},{"name":"Department of Pediatrics, University of Maryland School of Medicine, Baltimore, Maryland, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Myron M.","family":"Levine","sequence":"additional","affiliation":[{"name":"Center for Vaccine Development and Global Health, University of Maryland School of Medicine, Baltimore, Maryland, USA"},{"name":"Department of Medicine, University of Maryland School of Medicine, Baltimore, Maryland, USA"},{"name":"Department of Pediatrics, University of Maryland School of Medicine, Baltimore, Maryland, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sharon M.","family":"Tennant","sequence":"additional","affiliation":[{"name":"Center for Vaccine Development and Global Health, University of Maryland School of Medicine, Baltimore, Maryland, USA"},{"name":"Department of Medicine, University of Maryland School of Medicine, Baltimore, Maryland, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.7189\/jogh.02.010401"},{"key":"e_1_3_2_3_2","first-page":"346","article-title":"The global burden of typhoid fever","volume":"82","author":"Crump JA","year":"2004","unstructured":"Crump JA, Luby SP, Mintz ED. 2004. The global burden of typhoid fever. Bull World Health Organ 82:346\u2013353.","journal-title":"Bull World Health Organ"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.3201\/eid1111.050168"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.3201\/eid0503.990329"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.trstmh.2005.12.011"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.4161\/hv.29054"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/0264-410X(90)90183-M"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(87)90480-6"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1086\/518141"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(91)91910-M"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2012.07.051"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1128\/CVI.00058-12"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1038\/mi.2015.24"},{"key":"e_1_3_2_15_2","unstructured":"Reference deleted."},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2016.03.106"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1099\/00222615-26-4-285"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.41.9.4270-4278.2003"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1128\/mBio.00527-16"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.05278-11"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1128\/JB.184.3.645-653.2002"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2958.2003.03437.x"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(00)83397-8"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/0264-410X(91)90218-U"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-1157(80)80049-7"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.69.8.4734-4741.2001"},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.1038\/ng.195"},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0001373"},{"key":"e_1_3_2_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0264-410X(00)00142-0"},{"key":"e_1_3_2_30_2","article-title":"Multinational Salmonella Paratyphi B variant Java (Salmonella Java) outbreak, August\u2013December 2007","volume":"12","author":"Denny J","year":"2007","unstructured":"Denny J, Threlfall J, Takkinen J, Lofdahl S, Westrell T, Varela C, Adak B, Boxall N, Ethelberg S, Torpdahl M, Straetemans M, van Pelt W. 2007. Multinational Salmonella Paratyphi B variant Java (Salmonella Java) outbreak, August\u2013December 2007. Euro Surveill 12:E071220.2. https:\/\/www.eurosurveillance.org\/content\/10.2807\/esw.12.51.03332-en.","journal-title":"Euro Surveill"},{"key":"e_1_3_2_31_2","doi-asserted-by":"publisher","DOI":"10.3201\/eid1909.130334"},{"key":"e_1_3_2_32_2","doi-asserted-by":"publisher","DOI":"10.3201\/eid1205.051085"},{"key":"e_1_3_2_33_2","doi-asserted-by":"publisher","DOI":"10.3201\/eid1007.030862"},{"key":"e_1_3_2_34_2","doi-asserted-by":"publisher","DOI":"10.3201\/eid1101.031092"},{"key":"e_1_3_2_35_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.49.7.2793-2801.2005"},{"key":"e_1_3_2_36_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.00109-08"},{"key":"e_1_3_2_37_2","doi-asserted-by":"publisher","DOI":"10.7717\/peerj.332"},{"key":"e_1_3_2_38_2","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2105-11-119"},{"key":"e_1_3_2_39_2","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/bts565"},{"key":"e_1_3_2_40_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1306836110"},{"key":"e_1_3_2_41_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.00932-10"},{"key":"e_1_3_2_42_2","doi-asserted-by":"crossref","unstructured":"Sahl JW Beckstrom-Sternberg SM Babic-Sternberg J Gillece JD Hepp CM Auerbach RK Tembe W Wagner DM Keim PS Pearson T. 2015. The In Silico Genotyper (ISG): an open-source pipeline to rapidly identify and annotate nucleotide variants for comparative genomics applications. bioRxiv 015578. doi:10.1101\/015578.","DOI":"10.1101\/015578"},{"key":"e_1_3_2_43_2","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btu033"},{"key":"e_1_3_2_44_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkw290"},{"key":"e_1_3_2_45_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.120163297"},{"key":"e_1_3_2_46_2","doi-asserted-by":"publisher","DOI":"10.1016\/0378-1119(95)00193-A"},{"key":"e_1_3_2_47_2","unstructured":"Vindurampulle C Barry EM Levine MM Galen J. July 2013. Attenuated Salmonella enterica serovar Paratyphi A and uses thereof. US patent 8 475 810."},{"key":"e_1_3_2_48_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ab.2012.10.038"},{"key":"e_1_3_2_49_2","doi-asserted-by":"publisher","DOI":"10.1128\/CVI.00115-14"},{"key":"e_1_3_2_50_2","doi-asserted-by":"publisher","DOI":"10.1128\/CVI.00106-16"},{"key":"e_1_3_2_51_2","volume-title":"Guide for the care and use of laboratory animals","author":"National Research Council","year":"2011","unstructured":"National Research Council. 2011. Guide for the care and use of laboratory animals, 8th ed. National Academies Press, Washington, DC.","edition":"8"}],"container-title":["mSphere"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/mSphere.00474-18","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/mSphere.00474-18","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,8]],"date-time":"2022-03-08T04:16:27Z","timestamp":1646712987000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/mSphere.00474-18"}},"subtitle":[],"editor":[{"given":"Drusilla L.","family":"Burns","sequence":"additional","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2018,12,26]]},"references-count":50,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2018,12,26]]}},"alternative-id":["10.1128\/mSphere.00474-18"],"URL":"https:\/\/doi.org\/10.1128\/msphere.00474-18","relation":{},"ISSN":["2379-5042"],"issn-type":[{"type":"electronic","value":"2379-5042"}],"subject":[],"published":{"date-parts":[[2018,12,26]]},"assertion":[{"value":"2018-08-27","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-11-06","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-11-28","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e00474-18"}}