{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T08:42:24Z","timestamp":1790757744818,"version":"4.1.0"},"reference-count":55,"publisher":"American Society for Microbiology","issue":"6","license":[{"start":{"date-parts":[[2019,12,4]],"date-time":"2019-12-04T00:00:00Z","timestamp":1575417600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2019,12,18]],"date-time":"2019-12-18T00:00:00Z","timestamp":1576627200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"funder":[{"name":"Research Federation FRABio"},{"DOI":"10.13039\/501100001665","name":"Agence Nationale de la Recherche","doi-asserted-by":"publisher","award":["ANR-15-CE15-0002-01"],"award-info":[{"award-number":["ANR-15-CE15-0002-01"]}],"id":[{"id":"10.13039\/501100001665","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001677","name":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001677","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["mSphere"],"published-print":{"date-parts":[[2019,12,18]]},"abstract":"<jats:p>\n            <jats:named-content content-type=\"genus-species\">N. meningitidis<\/jats:named-content>\n            is transmitted from person to person by aerosol droplets produced by breathing, talking, or coughing or by direct contact with a contaminated fluid. The natural reservoir of\n            <jats:named-content content-type=\"genus-species\">N. meningitidis<\/jats:named-content>\n            is the human nasopharynx mucosa, located at the back of the nose and above the oropharynx. The means by which meningococci cross the nasopharyngeal wall is still under debate, due to the lack of a convenient and relevant model mimicking the nasopharyngeal niche. Here, we took advantage of Calu-3 cells grown in air interface culture to study how meningococci colonize the nasopharyngeal niche. We report that the airway mucus is both a niche for meningococcal growth and a protective barrier against\n            <jats:named-content content-type=\"genus-species\">N. meningitidis<\/jats:named-content>\n            infection. As such,\n            <jats:named-content content-type=\"genus-species\">N. meningitidis<\/jats:named-content>\n            behaves like commensal bacteria and is unlikely to induce infection without an external trigger.\n          <\/jats:p>","DOI":"10.1128\/msphere.00494-19","type":"journal-article","created":{"date-parts":[[2019,12,3]],"date-time":"2019-12-03T12:17:29Z","timestamp":1575375449000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":37,"title":["Airway Mucus Restricts Neisseria meningitidis Away from Nasopharyngeal Epithelial Cells and Protects the Mucosa from Inflammation"],"prefix":"10.1128","volume":"4","author":[{"given":"Mathilde","family":"Audry","sequence":"first","affiliation":[{"name":"INSERM, Unit\u00e9 U1151, Institut-Necker-Enfants-Malades, Paris, France"},{"name":"Universit\u00e9 de Paris, Facult\u00e9 de M\u00e9decine, Paris, France"},{"name":"CNRS, UMR 8253, Paris, 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