{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:32:53Z","timestamp":1787016773618,"version":"build-2736575974"},"reference-count":46,"publisher":"American Society for Microbiology","issue":"3","license":[{"start":{"date-parts":[[2020,6,17]],"date-time":"2020-06-17T00:00:00Z","timestamp":1592352000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2020,6,24]],"date-time":"2020-06-24T00:00:00Z","timestamp":1592956800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"funder":[{"DOI":"10.13039\/100000060","name":"HHS | NIH | National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["AI140010-02"],"award-info":[{"award-number":["AI140010-02"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["mSphere"],"published-print":{"date-parts":[[2020,6,24]]},"abstract":"<jats:p>\n                    <jats:named-content content-type=\"genus-species\">Clostridium perfringens<\/jats:named-content>\n                    type A strains produce toxins that are responsible for clostridial myonecrosis, also known as gas gangrene. Toxin production is regulated by an Agr-like quorum-sensing (QS) system that responds to changes in cell population density. In this study, we investigated the importance of this QS system in a mouse model of gas gangrene. Mice challenged with a\n                    <jats:named-content content-type=\"genus-species\">C. perfringens<\/jats:named-content>\n                    strain with a nonfunctional regulatory system developed less severe changes in the injected skeletal muscle compared to animals receiving the wild-type strain. In addition, a synthetic peptide was able to decrease the effects of the QS in this disease model. These studies provide new understanding of the pathogenesis of gas gangrene and identified a potential therapeutic target to prevent the disease.\n                  <\/jats:p>","DOI":"10.1128\/msphere.00500-20","type":"journal-article","created":{"date-parts":[[2020,6,17]],"date-time":"2020-06-17T09:13:35Z","timestamp":1592385215000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":20,"title":["The Agr-Like Quorum-Sensing System Is Important for\n                    <i>Clostridium perfringens<\/i>\n                    Type A Strain ATCC 3624 To Cause Gas Gangrene in a Mouse Model"],"prefix":"10.1128","volume":"5","author":[{"given":"Mauricio A.","family":"Navarro","sequence":"first","affiliation":[{"name":"California Animal Health and Food Safety Laboratory System, School of Veterinary Medicine, University of California, Davis, San Bernardino, California, 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